A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.

Nat Commun     Dick J H van den Boomen , Agata Sienkiewicz , Ilana Berlin , Marlieke L M Jongsma , Daphne M van Elsland , J Paul Luzio , Jacques J C Neefjes , Paul J Lehner

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

Mol Cell Proteomics     Molly M Hannigan , Alyson M Hoffman , J Will Thompson , Tianli Zheng , Christopher V Nicchitta

A High-Density Human Mitochondrial Proximity Interaction Network.

Cell Metab     Hana Antonicka , Zhen-Yuan Lin , Alexandre Janer , Mari J Aaltonen , Woranontee Weraarpachai , Anne-Claude Gingras , Eric A Shoubridge

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Cell Rep     Christian Haenig , Nir Atias , Alexander K Taylor , Arnon Mazza , Martin H Schaefer , Jenny Russ , Sean-Patrick Riechers , Shushant Jain , Maura Coughlin , Jean-Fred Fontaine , Brian D Freibaum , Lydia Brusendorf , Martina Zenkner , Pablo Porras , Martin Stroedicke , Sigrid Schnoegl , Kristin Arnsburg , Annett Boeddrich , Lucia Pigazzini , Peter Heutink , J Paul Taylor , Janine Kirstein , Miguel A Andrade-Navarro , Roded Sharan , Erich E Wanker

Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding.

Diabetes     Duc T Tran , Anita Pottekat , Saiful A Mir , Salvatore Loguercio , Insook Jang , Alexandre Rosa Campos , Kathleen M Scully , Reyhaneh Lahmy , Ming Liu , Peter Arvan , William E Balch , Randal J Kaufman , Pamela Itkin-Ansari

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

Nat. Cell Biol.     Paul M Müller , Juliane Rademacher , Richard D Bagshaw , Celina Wortmann , Carolin Barth , Jakobus van Unen , Keziban M Alp , Girolamo Giudice , Rebecca L Eccles , Louise E Heinrich , Patricia Pascual-Vargas , Marta Sanchez-Castro , Lennart Brandenburg , Geraldine Mbamalu , Monika Tucholska , Lisa Spatt , Maciej T Czajkowski , Robert-William Welke , Sunqu Zhang , Vivian Nguyen , Trendelina Rrustemi , Philipp Trnka , Kiara Freitag , Brett Larsen , Oliver Popp , Philipp Mertins , Anne-Claude Gingras , Frederick P Roth , Karen Colwill , Chris Bakal , Olivier Pertz , Tony Pawson , Evangelia Petsalaki , Oliver Rocks

Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.

Biochem Biophys Res Commun     Takumi Okamoto , Yan Wu , Koji Matsuhisa , Atsushi Saito , Fumika Sakaue , Kazunori Imaizumi , Masayuki Kaneko

The interactome of the prostate-specific protein Anoctamin 7.

Cancer Biomark     Elina Kaikkonen , Aliisa Takala , Juha-Pekka Pursiheimo , Gudrun Wahlström , Johanna Schleutker

PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.

Nat Cell Biol     Shao-Ming Shen , Cheng Zhang , Meng-Kai Ge , Shuang-Shu Dong , Li Xia , Ping He , Na Zhang , Yan Ji , Shuo Yang , Yun Yu , Jun-Ke Zheng , Jian-Xiu Yu , Qiang Xia , Guo-Qiang Chen

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

Sci Data     Giovanni Nassa , Giorgio Giurato , Annamaria Salvati , Valerio Gigantino , Giovanni Pecoraro , Jessica Lamberti , Francesca Rizzo , Tuula A Nyman , Roberta Tarallo , Alessandro Weisz