| Type | Description |
|---|---|
| Definition | SET and MYND domain containing 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:26:00 | Analysis of the of the SMYD2 Protein Lysine Methyltransferase and Discovery of Novel Non-Histone Substrates. | 31612581 |
| 2020-09-26 13:04:00 | Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis. | 31693890 |
| 2020-07-18 12:50:00 | Results reveal that the histone methyltransferase SMYD2 is dispensable in the undifferentiated hESCs and the early neuroectodermal differentiation, but it promotes the mesendodermal differentiation of hESCs through the epigenetic control of critical genes to mesendodermal lineage commitment. | 31348575 |
| 2020-06-20 10:43:00 | The recent surge of data on SMYD2 structure and function highlights that SMYD2 is a critical regulator of cardiovascular disease and cancer. Most studies have demonstrated that SMYD2 methylates nonhistone proteins to achieve its function, which is consistent with the fact that SMYD2 primarily localizes to the cytoplasm. [review] | 31370883 |
| 2019-11-30 12:31:00 | The expression of SMYD2 can be upregulated by and TNFalpha-NF-kappaB signaling, which integrates epigenetic regulation to inflammation in triple-negative breast cancer development. | 29487338 |
| Type | IDs |
|---|---|
| Synonymous | HSKM-B, KMT3C, ZMYND14 |
| Gene |
UniProtKB-ID:
SMYD2_HUMAN
UniprotKB:
Q9NRG4
UniParc:
UPI0000205E5F,
UPI000052FEAE
EMBL:
BC017080,
AF226053,
BC098276,
BC098305,
AL929236,
BC098133,
BC098335,
AK313868
Ensembl:
ENSG00000143499
KO:
hsa:56950
|
| Nucleutide sequences |
EMBL-CDS:
AAH98335.1,
AAH98276.1,
BAG36596.1,
AAH98305.1,
AAF86953.1,
AAH98133.1,
AAH17080.2
Ensembl_TRS:
ENST00000366957
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000355924
RefSeq:
NP_064582.2
|
| Others |
UniRef100:
UniRef100_Q9NRG4
UniRef90:
UniRef90_Q9NRG4
UniRef50:
UniRef50_Q9NRG4
UniGene:
Hs.66170
CCDS:
CCDS31022.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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