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56937 PMEPA1

56937

PMEPA1

prostate transmembrane protein, androgen induced 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition prostate transmembrane protein, androgen induced 1

研究结论

Date Results Publications
2020-11-28 13:15:00 PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1. 31605013
2020-10-24 14:08:00 PMEPA1/TMEPAI isoforms function via its PY and Smad-interaction motifs for tumorigenic activities of breast cancer cells. 32181976
2020-08-13 11:36:00 These data suggest that TMEPAI suppresses Wnt signaling by interfering with beta-catenin stability and nuclear translocation in a TGF-beta signaling-independent manner. 30890370
2020-07-25 11:20:00 Prostate transmembrane protein androgen induced 1 (PMEPA1) promotes colorectal cancer metastasis and epithelial-to-mesenchymal transition (EMT) in vivo and in vitro. 30887697
2019-06-01 13:17:00 observed that knockout (KO) of PMEPA1 in human breast cancer cell line MDA-MB-231 using a CRISPR-Cas9 system resulted in reduction of in vivo tumour growth and lung metastasis but not of in vitro monolayer growth capacity of these KO cell lines 30873542

名称对应

Type IDs
Synonymous STAG1, TMEPAI
Gene
UniProtKB-ID: PMEPA_HUMAN, Q5JY37_HUMAN
UniprotKB: Q969W9, Q5JY37
UniParc: UPI000006E885, UPI000004970A, UPI000002B575
EMBL: AK296199, BC015918, AF305426, AF305616, AY128643, AL121913, AL035541, AF224278, CH471077
Ensembl: ENSG00000124225
KO: hsa:56937
Nucleutide sequences
EMBL-CDS: AAM89277.1, EAW75508.1, AAL09357.1, AAH15918.2, AAL16781.1, EAW75505.1, AAF86322.1, EAW75506.1, BAG58927.1
Gene_ORFName: hCG_40101
Ensembl_TRS: ENST00000265626, ENST00000395816, ENST00000341744, ENST00000347215, ENST00000395814
Protein sequencees
Ensembl_PRO: ENSP00000379161, ENSP00000265626, ENSP00000345826, ENSP00000344014, ENSP00000379159
RefSeq: NP_954640.1, NP_001242905.1, NP_064567.2, NP_954638.1, NP_954639.1
Others
UniRef100: UniRef100_Q969W9, UniRef100_Q5JY37
UniRef90: UniRef90_Q969W9
UniRef50: UniRef50_Q969W9
UniGene: Hs.517155
CCDS: CCDS13462.1, CCDS13463.1, CCDS13464.1

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