| Type | Description |
|---|---|
| Definition | signal peptide peptidase like 2B |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 10:25:00 | SPPL2a/b negatively regulates LOX-1 signaling and atherosclerosis. | 30819724 |
| 2013-05-25 10:31:00 | TfR1 N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b. | 23384347 |
| 2012-04-21 12:01:00 | The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). | 22194595 |
| 2010-01-21 00:00:00 | SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER. | 15998642 |
| 2010-01-21 00:00:00 | Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha and caused a relative increase of longer intracellular cleavage products. | 18768471 |
| Type | IDs |
|---|---|
| Synonymous | IMP-4, IMP4, PSH4, PSL1 |
| Gene |
UniProtKB-ID:
SPP2B_HUMAN
UniprotKB:
Q8TCT7
UniParc:
UPI0000D473B2,
UPI00005A8936,
UPI0000033768
EMBL:
BC093046,
AB040965,
BC028391,
AC004410,
CH471139,
AC005258,
AY169315,
AJ345027,
AL365405,
BC001788,
AJ420897
Ensembl:
ENSG00000005206
KO:
hsa:56928
|
| Nucleutide sequences |
EMBL-CDS:
AAC05601.1,
EAW69383.1,
AAH93046.1,
AAO12540.1,
BAA96056.1,
CAC87788.1,
CAB96951.1,
EAW69388.1,
AAH01788.2,
CAD13134.1,
AAH28391.2,
AAG45441.1
Ensembl_TRS:
ENST00000618220,
ENST00000613503,
ENST00000610743
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000478510,
ENSP00000480813,
ENSP00000478298
RefSeq:
XP_016882505.1,
XP_016882506.1,
NP_001070706.1,
XP_011526441.1,
XP_024307387.1,
XP_011526442.1,
XP_011526440.1,
XP_016882507.1,
XP_016882508.1,
NP_694533.1
|
| Others |
UniRef100:
UniRef100_Q8TCT7
UniRef90:
UniRef90_Q8TCT7
UniRef50:
UniRef50_Q8TCT7
UniGene:
Hs.744026
CCDS:
CCDS74253.1,
CCDS74252.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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