| Type | Description |
|---|---|
| Definition | transcriptional and immune response regulator |
| Date | Results | Publications |
|---|---|---|
| 2020-09-12 15:58:00 | Correlations of ultrasound and pathological features of thyroid carcinoma with TC-1 mRNA and protein expression. | 31081098 |
| 2020-06-06 10:30:00 | The lncRNA H19 serves as a competing endogenous RNA (ceRNA) for miR-30a to augment miR-30a downstream target C8orf4, therefore modulating adipogenic differentiation in adipose tissue-derived mesenchymal stem cells. | 31026067 |
| 2019-10-12 12:43:00 | The expressions of C8orf4 (TCIM) and beta-catenin increase synergystically in cervical squamous cell carcinoma (CSCC) and high-grade intraepithelial lesions compared with low-grade lesions and normal cervical tissues. The methylation level of C8orf4 is decreased in CSCCs and is responsible for the increased expression of C8orf4. | 31374065 |
| 2018-12-01 10:07:00 | Identified a new circRNA, circZFR, that was significantly upregulated in papillary thyroid carcinoma (PTC). CircZFR could promote C8orf4 expression via serving as a competing endogenous RNA of miR-1261 in PTC cells. Rescue assays indicated that restoration of C8orf4 significantly attenuated the inhibitory effects of circZFR knockdown on PTC cell proliferation, migration and invasion. | 29842886 |
| 2016-07-30 10:39:00 | Decreased capacity of fibrotic lung fibroblasts to up-regulate COX-2 expression and COX-2-derived PGE2 synthesis is due to an indirect epigenetic mechanism involving hypermethylation of the transcriptional regulator, c8orf4. | 26744410 |
| Type | IDs |
|---|---|
| Synonymous | C8orf4, TC-1, TC1 |
| Gene |
UniProtKB-ID:
TCIM_HUMAN
UniprotKB:
Q9NR00
UniParc:
UPI000013FBD4
EMBL:
AF268037,
BC020623,
BC021672,
AC022733
Ensembl:
ENSG00000176907
KO:
hsa:56892
|
| Nucleutide sequences |
EMBL-CDS:
AAF78961.1,
AAH21672.1,
AAH20623.1
Ensembl_TRS:
ENST00000315792
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000319914
RefSeq:
NP_064515.2
|
| Others |
UniRef100:
UniRef100_Q9NR00
UniRef90:
UniRef90_Q9NR00
UniRef50:
UniRef50_Q9NR00
UniGene:
Hs.591849,
Hs.745031
CCDS:
CCDS6115.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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