| Type | Description |
|---|---|
| Definition | dickkopf WNT signaling pathway inhibitor 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-07 11:32:00 | In the absence of Dkk2, Wnt/beta-catenin signaling activity is initially broadly elevated in embryonic plantar skin and gradually becomes patterned, mimicking follicular development in normally haired areas. | 30509557 |
| 2019-07-20 10:14:00 | Reprogramming of damaged erectile tissue toward neurovascular repair by use of a DKK2 therapeutic protein may represent viable treatment option for this condition. | 29259207 |
| 2018-06-30 12:15:00 | Data (including data from studies in transgenic mice) suggest that Dkk2 secreted from pericytes promotes angiogenesis and neurogenesis/neural regeneration via Angpt1/Tie2/Wnt signaling; here, overexpression of Dkk2 in diabetic mice enhances penile angiogenesis/neural regeneration and restores erectile function. (Dkk2 = dickkopf-2; Angpt1= angiopoietin-1; Tie2 = endothelial-specific receptor tyrosine kinase Tie2) | 29559443 |
| 2018-01-13 14:12:00 | Dkk2 deletion results in alterations of liver morphology leading to an increased frequency of liver cancer | 25826080 |
| 2017-07-22 10:24:00 | Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development. | 27053129 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
DKK2_MOUSE
UniprotKB:
Q9QYZ8
UniParc:
UPI0000022D8D
EMBL:
AK031749,
BC096448,
AK028225,
AC127260,
CH466532,
AJ243963
Ensembl:
ENSMUSG00000028031
KO:
mmu:56811
|
| Nucleutide sequences |
EMBL-CDS:
EDL12195.1,
BAC27536.1,
BAC25824.1,
CAB60110.1,
AAH96448.1
Ensembl_TRS:
ENSMUST00000029665
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000029665
RefSeq:
XP_006501881.1,
NP_064661.2
|
| Others |
UniRef100:
UniRef100_Q9QYZ8
UniRef90:
UniRef90_Q9QYZ8
UniRef50:
UniRef50_Q9QYZ8
UniGene:
Mm.103593
CCDS:
CCDS17844.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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