| Type | Description |
|---|---|
| Definition | large tumor suppressor kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 10:59:00 | Results provide evidence supporting the role for Hippo-Yap/Taz signaling in peripheral nerve sheath tumor (PNST) formation by presenting a novel model of PNSTs in zebrafish. Somatic inactivation of the Hippo kinase Lats2 by mosaic CRISPR-Cas9 gene editing resulted in obvious tumorigenesis. Histological examination of the resulting tumors identified them as resembling PNST in morphology. | 31450674 |
| 2014-02-08 11:06:00 | Thus AMOT is a direct substrate of Lats1/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis. | 24106267 |
| 2010-02-15 11:31:00 | lats genes show distinctly different expression profiles during gastrulation. lats1 is almost ubiquitously expressed through development, and lats2 is more prominently expressed in the non-neural ectoderm region of zebrafish gastrula. | 19842174 |
| Type | IDs |
|---|---|
| Synonymous | si:ch211-173o4.2 |
| Gene |
UniProtKB-ID:
B0S8I4_DANRE,
B2BJC0_DANRE,
B2BJC1_DANRE
UniprotKB:
B0S8I4,
B2BJC0,
B2BJC1
UniParc:
UPI0000F1EB8A,
UPI000171CCEA,
UPI000171CCE9
EMBL:
EF524200,
EF524199,
BX936339,
BX511129
Ensembl:
ENSDARG00000078864
KO:
dre:567674
|
| Nucleutide sequences |
EMBL-CDS:
ABS88160.1,
ABS88161.1
Ensembl_TRS:
ENSDART00000111899,
ENSDART00000139620,
ENSDART00000113352
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000102587,
ENSDARP00000114142,
ENSDARP00000098124
RefSeq:
NP_001116779.1,
NP_001121728.1,
XP_005167636.1,
XP_021334416.1
|
| Others |
UniRef100:
UniRef100_B2BJC0,
UniRef100_B2BJC1,
UniRef100_B0S8I4
UniRef90:
UniRef90_B0S8I4
UniRef50:
UniRef50_Q9NRM7
UniGene:
Dr.84188
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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