| Type | Description |
|---|---|
| Definition | platelet factor 4 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-14 10:54:00 | ELF4 binds to the promoter of genes of two C-X-C chemokines, Pf4 and pro-platelet basic protein (Ppbp), initiating the transcription of these two genes, thereby enhancing PF4-mediated killing of parasites from infected erythrocytes. | 30898878 |
| 2019-04-06 10:53:00 | Platelets are activated during P. aeruginosa infection, and mice depleted of platelets display markedly increased mortality and impaired bacterial clearance. CXCL4 deficiency impairs bacterial clearance and lung epithelial permeability. CXCL4 deficiency selectively regulates chemokine production. CXCL4 deficiency reduces platelet-neutrophil interactions in blood following P. aeruginosa infection. | 30296305 |
| 2018-07-07 11:27:00 | these data demonstrate that PF4 has an important role in increasing B cell differentiation in the bone marrow environment | 28914425 |
| 2018-06-02 10:29:00 | these results identify CXCL4 as a vital immunoregulatory chemokine essential for protecting mice against influenza A virus infection, especially as it affects the development of lung injury and neutrophil mobilization to the inflamed lung | 28120850 |
| 2018-04-21 11:29:00 | These results indicate that CXCL4 is a novel Ni-binding protein that augments Ni allergy at the elicitation and sensitization phases. This is the first study to demonstrate that the Ni-binding protein augments Ni allergy in vivo. | 28319310 |
| Type | IDs |
|---|---|
| Synonymous | Cxcl4, Scyb4 |
| Gene |
UniProtKB-ID:
PLF4_MOUSE,
Q6P8R3_MOUSE,
Q3TVN6_MOUSE
UniprotKB:
Q9Z126,
Q6P8R3,
Q3TVN6
UniParc:
UPI0000213205,
UPI00000231AD
EMBL:
BC061111,
AF349465,
AK160040,
AK159278,
AB017491
Ensembl:
ENSMUSG00000029373
KO:
mmu:56744
|
| Nucleutide sequences |
EMBL-CDS:
BAA75660.1,
AAK30163.1,
AAH61111.1,
BAE35582.1,
BAE34956.1
Ensembl_TRS:
ENSMUST00000031320
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000031320
RefSeq:
NP_064316.1
|
| Others |
UniRef100:
UniRef100_Q6P8R3,
UniRef100_Q9Z126
UniRef90:
UniRef90_Q9Z126
UniRef50:
UniRef50_P02776
UniGene:
Mm.332490
CCDS:
CCDS19416.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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