| Type | Description |
|---|---|
| Definition | tryptophan 2,3-dioxygenase |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:00:00 | The autoimmune response elicited by mouse hepatitis virus (MHV-A59) infection is modulated by liver tryptophan-2,3-dioxygenase (TDO). | 31726186 |
| 2019-09-21 11:36:00 | Tdo2 deficiency had no significant effects on such as prepulse inhibition, depression-like and social behaviors. | 30106261 |
| 2018-11-03 10:11:00 | TDO-deficiency protected from neuronal loss in the spinal cord but not in the optic nerves. | 28117398 |
| 2018-05-05 10:58:00 | Study demonstrated that n-butylidenephthalide (n-BP)functions by regulating the early part of the kynurenine pathway through the downregulation of tryptophan 2, 3-dioxygenase (TDO2), which decreases the downstream neurotoxic product, quinolinic acid (QA). Findings indicate a correlation between n-BP, TDO2, QA, calpain, and toxic fragment formation. | 28223212 |
| 2018-04-14 11:40:00 | Data suggest that Indoleamine 2,3-dioxygenase 1 (IDO1) appears to be a potential hallmark of liver lesions, and its deficiency protects mice from CCl4-induced fibrosis mediated by Th17 cells down-regulation and tryptophan 2,3-dioxygenase (TDO) compensatory increase. | 28465467 |
| Type | IDs |
|---|---|
| Synonymous | AA407491, TDO, TO, chky |
| Gene |
UniProtKB-ID:
T23O_MOUSE,
Q8VCW3_MOUSE
UniprotKB:
P48776,
Q8VCW3
UniParc:
UPI0000022D80
EMBL:
U24493,
AC159260,
BC018390,
AB476989
Ensembl:
ENSMUSG00000028011
KO:
mmu:56720
|
| Nucleutide sequences |
EMBL-CDS:
AAB60491.1,
BAH84762.1,
AAH18390.1
Ensembl_TRS:
ENSMUST00000029645
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000029645
RefSeq:
NP_064295.2
|
| Others |
UniRef100:
UniRef100_P48776
UniRef90:
UniRef90_P21643
UniRef50:
UniRef50_P48775
UniGene:
Mm.258622
CCDS:
CCDS17427.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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