| Type | Description |
|---|---|
| Definition | RAB guanine nucleotide exchange factor (GEF) 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:04:00 | Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration. | 33362196 |
| 2021-01-09 13:31:00 | Epithelial RABGEF1 deficiency promotes intestinal inflammation by dysregulating intrinsic MYD88-dependent innate signaling. | 31628426 |
| 2018-06-09 10:51:00 | AP-1/sigma1A-ArfGAP1-Rabex-5 complex formation leads to more endosomal Rabex-5 and enhanced, Rab5(GTP)-stimulated Vps34 PI3-kinase activity, which is essential for multivesicular body endosome formation. | 27411398 |
| 2017-09-02 11:04:00 | findings reveal a key role for RABGEF1 in dampening keratinocyte-intrinsic MYD88 signaling and sustaining epidermal barrier function | 27820702 |
| 2015-12-26 10:27:00 | Knockdown of RABEX-5 also inhibited wound healing, migration and the invasive abilities of gastric cancer cells. | 25427001 |
| Type | IDs |
|---|---|
| Synonymous | Rab5ef, Rabex5, Rin2 |
| Gene |
UniProtKB-ID:
RABX5_MOUSE
UniprotKB:
Q9JM13
UniParc:
UPI00000225D1
EMBL:
AF093590,
BC018229,
AK044568,
AK146734
Ensembl:
ENSMUSG00000025340
KO:
mmu:56715
|
| Nucleutide sequences |
EMBL-CDS:
AAH18229.1,
BAE27396.1,
BAC31984.1,
AAF28738.1
Ensembl_TRS:
ENSMUST00000026390,
ENSMUST00000119797
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026390,
ENSMUSP00000114103
RefSeq:
NP_001365802.1,
NP_064367.1,
NP_001185988.1,
NP_001346162.1,
XP_006504510.1,
XP_006504509.1,
XP_036021251.1,
XP_036021249.1
|
| Others |
UniRef100:
UniRef100_Q9JM13
UniRef90:
UniRef90_Q9JM13
UniRef50:
UniRef50_Q9JM13
UniGene:
Mm.288639
CCDS:
CCDS19708.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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