| Type | Description |
|---|---|
| Definition | Rap guanine nucleotide exchange factor (GEF) 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:18:00 | Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. | 31551444 |
| 2020-07-11 11:34:00 | The present data suggest that a cAMP signaling pathway via Epac2 may be party to adult neurogenesis. | 31870404 |
| 2020-07-11 10:08:00 | When glucose metabolism induces insulin secretion, it also increases formation of Golgi-derived microtubules (GDMTs), notably with the same biphasic kinetics as insulin exocytosis. Furthermore, GDMT nucleation is controlled by a glucose signal-transduction pathway through cAMP and its effector EPAC2. | 31303487 |
| 2020-06-27 10:07:00 | Barr1 can directly interact with Epac2; sulfonylureas such as glibenclamide promote Barr1/Epac2 complex formation, triggering enhanced Rap1 signaling and insulin secretion | 31184597 |
| 2020-06-06 11:25:00 | Epac has a protecting effect on asthmatic airway inflammation and airway remodeling, and reduces airway smooth muscle cells proliferation by inhibiting SOCE. | 31852500 |
| Type | IDs |
|---|---|
| Synonymous | 1300003D15Rik, 5730402K07Rik, 6330581N18Rik, EPAC 2, Epac-2, Epac2, mKIAA4040 |
| Gene |
UniProtKB-ID:
RPGF4_MOUSE,
Q9CS95_MOUSE,
A2ASW8_MOUSE,
A2ASW4_MOUSE,
Q571A8_MOUSE
UniprotKB:
Q9EQZ6,
Q9CS95,
A2ASW8,
A2ASW4,
Q571A8
UniParc:
UPI0000029BD1,
UPI00004FF434,
UPI00000E7C49,
UPI0000D77805,
UPI00000275D2,
UPI0000027896
EMBL:
AK220281,
AB021132,
BC139822,
AL928617,
AK017479,
AK004874,
AB037668,
AL929498,
AB445011,
AL928699,
AF115480
Ensembl:
ENSMUSG00000049044
KO:
mmu:56508
|
| Nucleutide sequences |
EMBL-CDS:
BAB72180.1,
AAD09132.1,
BAB23633.1,
BAB18976.1,
BAB30763.1,
BAH30656.1,
AAI39823.1,
BAD90206.1
Ensembl_TRS:
ENSMUST00000102698,
ENSMUST00000090826,
ENSMUST00000028525
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000088336,
ENSMUSP00000099759,
ENSMUSP00000028525
RefSeq:
NP_001342407.1,
NP_062662.1,
NP_001191096.1,
XP_030107759.1,
NP_001191094.1,
XP_036018308.1,
XP_006500001.1,
NP_001191095.1
|
| Others |
UniRef100:
UniRef100_A2ASW8,
UniRef100_Q9EQZ6,
UniRef100_Q9CS95
UniRef90:
UniRef90_A0A4X2LXB4,
UniRef90_Q9EQZ6,
UniRef90_Q9CS95
UniRef50:
UniRef50_Q9CS95,
UniRef50_Q9EQZ6
UniGene:
Mm.196153
CCDS:
CCDS16120.1,
CCDS57176.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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