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56478 EIF4ENIF1

56478

EIF4ENIF1

eukaryotic translation initiation factor 4E nuclear import factor 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition eukaryotic translation initiation factor 4E nuclear import factor 1

研究结论

Date Results Publications
2017-06-24 11:43:00 we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis. 27342281
2016-04-16 11:30:00 our data support a model where 4E-T promotes mRNA turnover by physically linking the 3'-terminal mRNA decay machinery to the 5' cap 26027925
2015-02-14 11:22:00 neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis. 25456498
2014-06-21 11:36:00 that while both eIF4E1 and eIF4E2 bind 4E-T via the canonical YX 4Lvarphi sequence, nearby downstream sequences also influence eIF4E:4E-T interactions 23991149
2014-05-24 11:20:00 This work has demonstrated the conserved yet unpredicted and surprising translational control of bound mRNAs by 4E-T, which does not involve eIF4E, nor P-body components. 24335285

名称对应

Type IDs
Synonymous 4E-T, Clast4
Gene
UniProtKB-ID: 4ET_HUMAN, A0A024R1K0_HUMAN
UniprotKB: Q9NRA8, A0A024R1K0
UniParc: UPI000016A006, UPI00033362AB, UPI0000124F14
EMBL: BC033028, AK074768, CR456386, CH471095, AK025254, AL096701, BC032941, AF240775, AK314636
Ensembl: ENSG00000184708
KO: hsa:56478
Nucleutide sequences
EMBL-CDS: CAG30272.1, AAF81693.1, BAC11194.1, AAH33028.1, BAG37198.1, EAW59977.1, AAH32941.1, BAB15092.1, EAW59979.1, EAW59978.1
Gene_ORFName: hCG_41518
Ensembl_TRS: ENST00000344710, ENST00000330125, ENST00000397525
Protein sequencees
Ensembl_PRO: ENSP00000342927, ENSP00000328103, ENSP00000380659
RefSeq: XP_006724344.3, NP_001157974.1, NP_001157973.1, XP_016884353.1, XP_005261744.1, XP_016884352.1, XP_011528583.1, XP_005261743.1, NP_062817.2, XP_011528582.1, XP_005261745.1
Others
UniRef100: UniRef100_Q9NRA8
UniRef90: UniRef90_Q9NRA8
UniRef50: UniRef50_Q9NRA8
UniGene: Hs.517559
CCDS: CCDS13898.1, CCDS54520.1

全选

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