| Type | Description |
|---|---|
| Definition | STIP1 homology and U-Box containing protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-28 13:16:00 | CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury. | 33082318 |
| 2019-10-26 12:08:00 | Proteomic analysis of WT and CHIP KO mouse brains reveals proteins essential for maintaining energetic, redox, and mitochondrial homeostasis undergo genotype-dependent expression changes. CHIP is an essential regulator of mitochondrial number,signaling, survival. | 29934347 |
| 2019-09-21 10:49:00 | In summary, these results suggest that CHIP regulates AQP2 and subsequently, renal water handling. | 29242247 |
| 2019-08-10 12:42:00 | The existence of a multiprotein complex containing UBXN2A, CHIP, and mot-2 suggests a synergistic tumor suppressor activity of UBXN2A and CHIP in mot-2-enriched tumors. | 30107089 |
| 2019-01-19 11:12:00 | Study using two rodent models demonstrated that T246M mutation (described in autosomal recessive spinocerebellar ataxia-16 patients) results in structural disorganization and misfolding of the CHIP U-box domain, promoting oligomerization, and increased proteasome-dependent turnover. CHIP-T246M has no ligase activity but maintains interactions with chaperones and chaperone-related functions. | 30222779 |
| Type | IDs |
|---|---|
| Synonymous | 0610033N24Rik, 2210017D18Rik, 2310040B03Rik, AW046544, Chip |
| Gene |
UniProtKB-ID:
CHIP_MOUSE
UniprotKB:
Q9WUD1
UniParc:
UPI0000025E9D
EMBL:
BC027427,
AK002752,
AF129086,
AK045776,
BC038939,
AK166630,
AK004464
Ensembl:
ENSMUSG00000039615
KO:
mmu:56424
|
| Nucleutide sequences |
EMBL-CDS:
BAB22329.1,
BAB23315.1,
BAC32489.1,
AAH38939.1,
AAH27427.1,
AAD33401.1,
BAE38905.1
Ensembl_TRS:
ENSMUST00000044911
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000040431
RefSeq:
NP_062693.1
|
| Others |
UniRef100:
UniRef100_Q9WUD1
UniRef90:
UniRef90_Q9WUD1
UniRef50:
UniRef50_Q9WUD1
UniGene:
Mm.277599,
Mm.491120
CCDS:
CCDS28533.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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