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56401 P3h1

56401

P3h1

prolyl 3-hydroxylase 1

protein-coding

Mus musculus

基因描述

Type Description
Definition prolyl 3-hydroxylase 1

研究结论

Date Results Publications
2016-12-17 11:18:00 P3H1 deficiency leads to decreased deposition of extracellular matrix by osteoblasts and increased incorporation of mineral into the matrix. 26808442
2014-06-21 13:01:00 we generated knock-in mice carrying a single amino acid substitution in the catalytic site of P3h1 (Lepre1(H662A) ). This substitution abolished P3h1 activity but retained ability to form a complex with Crtap and thus the collagen chaperone 24465224
2014-01-04 13:17:00 An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. 24043621
2013-11-16 10:04:00 The absence of 3-hydroxyproline and/or the increased glycosylation of hydroxylysine in type I collagen disturbs the lateral growth of the fibrils. 23861401
2013-07-27 12:26:00 The LEPRE1 knockout mouse is a valuable model system to investigate the mechanism of hearing loss in recessive osteogenesis imperfecta. 23186870

名称对应

Type IDs
Synonymous 2410024C15Rik, Gros1, Lepre1
Gene
UniProtKB-ID: P3H1_MOUSE, A6PW84_MOUSE, A2A7Q5_MOUSE
UniprotKB: Q3V1T4, A6PW84, A2A7Q5
UniParc: UPI00001F13EA, UPI0000D89842, UPI0001574854, UPI0000D89843, UPI000059E0BD
EMBL: AK132262, BC024047, AF165163, AK159505, AL606975, AF165164, AK010578, AK030436
Ensembl: ENSMUSG00000028641
KO: mmu:56401
Nucleutide sequences
EMBL-CDS: BAB27041.1, BAC26962.1, BAE21065.1, AAF04807.1, BAE35138.1, AAF04806.1, AAH24047.1
Ensembl_TRS: ENSMUST00000121111, ENSMUST00000081606, ENSMUST00000030393, ENSMUST00000102662
Protein sequencees
Ensembl_PRO: ENSMUSP00000112504, ENSMUSP00000080312, ENSMUSP00000030393, ENSMUSP00000099723
RefSeq: NP_001035874.1, NP_062757.2, NP_001273077.1, NP_062756.2
Others
UniRef100: UniRef100_A6PW84, UniRef100_A2A7Q5, UniRef100_Q3V1T4
UniRef90: UniRef90_Q3V1T4
UniRef50: UniRef50_Q32P28
UniGene: Mm.27961
CCDS: CCDS38859.1, CCDS38860.1

全选

研究热度
发表文献
热点单位
排名 科研单位 文献
1

University of Washington

2
2

Research Department, Shriners Hospitals for Children, Portland, Oregon 97239, USA.

2
3

Research Department, Shriners Hospital for Children, Portland, Oregon 97239, USA.

2
4

Wellcome Trust Sanger Institute

1
5

Yokohama Institute

1
热点人员
排名 研究人员 文献
1

P Carninci

7
2

Y Hayashizaki

6
3

Hans Peter Bächinger

6
4

K Shibata

5
5

M Itoh

5
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