| Type | Description |
|---|---|
| Definition | ADP-ribosylation factor-like 3 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-11 13:19:00 | In a mouse germline knockout of RP2, ARL3-GTP is abundant as its intrinsic GTPase activity is extremely low. High levels of ARL3-GTP impair binding and trafficking of cargo to the outer segment. This knockout is embryonically lethal causing a syndromic ciliopathy-like phenotype. The knockouts reveal binary functions of ARL3-GTP as a key molecule in late-stage photoreceptor ciliogenesis and cargo displacement. Review. | 29721959 |
| 2017-07-29 11:36:00 | this study identifies ARL3 as a key player in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role for ARL3 dysregulation in the pathogenesis of RP2-related forms of X-linked retinitis pigmentosa | 26936825 |
| 2017-07-08 10:09:00 | Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).( | 28487361 |
| 2016-08-27 12:33:00 | The authors show that the ciliary G-protein Arl13B, mutated in Joubert syndrome, is the guanine nucleotide exchange factor for Arl3, and its function is conserved in evolution | 26551564 |
| 2016-08-06 10:16:00 | ARL3 regulates protein trafficking and ciliogenesis in mouse photoreceptors. | 26814127 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
ARL3_MOUSE,
Q543P7_MOUSE
UniprotKB:
Q9WUL7,
Q543P7
UniParc:
UPI0000004093
EMBL:
BC042941,
AK048644,
AF143241
Ensembl:
ENSMUSG00000025035
KO:
mmu:56350
|
| Nucleutide sequences |
EMBL-CDS:
AAH42941.1,
AAD33067.1,
BAC33407.1
Ensembl_TRS:
ENSMUST00000026009
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026009
RefSeq:
NP_001342162.1,
NP_062692.1
|
| Others |
UniRef100:
UniRef100_Q9WUL7
UniRef90:
UniRef90_Q9WUL7
UniRef50:
UniRef50_Q9WUL7
UniGene:
Mm.22085
CCDS:
CCDS38010.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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