| Type | Description |
|---|---|
| Definition | Ras association (RalGDS/AF-6) domain family member 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 12:02:00 | The RASSF1A negatively regulates NF-kappaB and thereby attenuates inflammatory cytokine expression. | 31311858 |
| 2020-02-29 10:17:00 | Findings indicate that compared with the alcoholic steatohepatitis (ASH) group of patients, the expression levels of all three tumor suppressor genes (TSGs) proteins, RUNX family transcription factor 3 (RUNX3), glutathione S-transferase pi 1 (GSTP1), and RASSF1A tumor suppressor (RASSF1), were significantly lower in the non-alcoholic steatohepatitis (NASH) group of patients. | 30951700 |
| 2020-01-04 11:47:00 | The authors show that an antisense lncRNA of RASSF1A inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice, indicating a potential application of RASSF1-AS1 as a therapy target for cardiac fibrosis. | 30571844 |
| 2019-06-15 12:28:00 | Study show that hypoxia promotes stabilization of RASSF1A through NOX-1- and protein kinase C- dependent phosphorylation. HIF-1alpha activates RASSF1A transcription via HIF-binding sites in the RASSF1A promoter region. RASSF1A binds to HIF-1alpha, blocks its prolyl-hydroxylation and proteasomal degradation. Study concludes that RASSF1A-HIF-1alpha forms a feedforward loop driving hypoxia signaling in pulmonary hypertens... | 31086178 |
| 2019-06-15 12:20:00 | The authors found that haploinsufficiency of Rassf1a was sufficient to dramatically enhance the tumorigenicity of K-Ras in the system. | 29735543 |
| Type | IDs |
|---|---|
| Synonymous | 123F2, AA536941, AU044980, NORE2A, RDA32, REH3P21, Rassf1A, Rassf1B, Rassf1C |
| Gene |
UniProtKB-ID:
RASF1_MOUSE,
Q3UIV8_MOUSE,
A9YZW8_MOUSE
UniprotKB:
Q99MK9,
Q3UIV8,
A9YZW8
UniParc:
UPI000002117A,
UPI00001F7E52,
UPI0000021179
EMBL:
BC002173,
AF132851,
AK146736,
AF333027,
EU314810
Ensembl:
ENSMUSG00000010067
KO:
mmu:56289
|
| Nucleutide sequences |
EMBL-CDS:
AAD30061.1,
AAH02173.1,
AAK21200.1,
AAK21201.1,
BAE27398.1,
ABY27299.1
Ensembl_TRS:
ENSMUST00000010211,
ENSMUST00000093786
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000010211,
ENSMUSP00000091301
RefSeq:
XP_006511833.1,
NP_001230677.1,
XP_036011035.1,
NP_062687.1
|
| Others |
UniRef100:
UniRef100_Q99MK9,
UniRef100_Q3UIV8
UniRef90:
UniRef90_Q9NS23-5,
UniRef90_A0A2R9C9I6
UniRef50:
UniRef50_Q9NS23-3,
UniRef50_G1KI15
UniGene:
Mm.12091,
Mm.488708
CCDS:
CCDS23494.1,
CCDS57699.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员