| Type | Description |
|---|---|
| Definition | proline dehydrogenase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 13:02:00 | Understanding the role of key amino acids in regulation of proline dehydrogenase/proline oxidase (prodh/pox)-dependent apoptosis/autophagy as an approach to targeted cancer therapy. | 31933109 |
| 2019-04-20 11:24:00 | Proline Dehydrogenase (PRODH) expression is reduced in human with Heart Failure. PRODH appears to be crucial to sustain normal mitochondrial function and maintenance of ATP levels in human cardiomyocytes in a hypoxic environment, as well as for redox homeostasis in both normoxic and hypoxic conditions. | 30867130 |
| 2018-12-22 11:31:00 | PRODH1-mediated proline metabolism promotes pancreatic ductal adenocarcinoma growth. | 28685754 |
| 2017-12-02 11:40:00 | Here, we show that Prodh-deficient mice with elevated CNS L-proline display specific deficits in high-frequency GABA-ergic transmission and gamma-band oscillations. We find that L-proline is a GABA-mimetic and can act at multiple GABA-ergic targets | 27705802 |
| 2017-11-04 10:49:00 | PRODH/POX knockdown decreased DNA and collagen biosynthesis, whereas increased prolidase activity and intracellular proline level in MCF-7shPRODH/POX cells. | 28942439 |
| Type | IDs |
|---|---|
| Synonymous | HSPOX2, PIG6, POX, PRODH1, PRODH2, TP53I6 |
| Gene |
UniProtKB-ID:
PROD_HUMAN
UniprotKB:
O43272
UniParc:
UPI0000E8A8E2,
UPI000016991D,
UPI0000DBEBBB
EMBL:
U79754,
BC094736,
BC118597,
AF010310,
AF120278,
BC068260,
AC007326,
U82381,
BC121809,
AB209472
Ensembl:
ENSG00000100033
KO:
hsa:5625
|
| Nucleutide sequences |
EMBL-CDS:
AAI18598.1,
BAD92709.1,
AAF21464.1,
AAI21810.1,
AAB88789.1,
AAH94736.1,
AAH68260.1,
AAD24775.1,
AAC39529.1
Ensembl_TRS:
ENST00000357068
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000349577
RefSeq:
NP_001182155.2,
NP_057419.5
|
| Others |
UniRef100:
UniRef100_O43272
UniRef90:
UniRef90_O43272
UniRef50:
UniRef50_O43272
UniGene:
Hs.517352
CCDS:
CCDS13754.1,
CCDS56223.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员