| Type | Description |
|---|---|
| Definition | melanocortin 2 receptor accessory protein |
| Date | Results | Publications |
|---|---|---|
| 2018-06-09 10:18:00 | allele of the 5 insertion/deletion polymorphism in the Alpha-2-MRAP gene is related with an increase of oxidative stress in nephrolithiasis patients | 28760704 |
| 2018-05-26 10:20:00 | Data (including data from studies in transgenic mice) suggest that MRAP plays critical role in (1) regulation of lipolysis in adipose tissue, (2) regulation of enzyme expression in adipose tissue, and (3) whole-body energy balance. | 29217655 |
| 2016-10-22 11:29:00 | MRAP expression in human cell line results in an ACTH responsive phenotype. | 26576642 |
| 2016-06-11 11:58:00 | Data show that co-expression with MRAPalpha, but not MRAP2, enhances MC4R constitutive activity. MRAPalpha-enhanced MC4R constitutive activity is not dependent on MC4R complex glycosylation but may result from MRAPalpha-induced changes in MC4R conformational states. | 26469516 |
| 2016-03-12 10:16:00 | The results firmly establish that only the copy of MRAP oriented with the amino terminus on the extracellular side of the receptor is essential for Adrenocorticotropic Hormone signal transduction. | 26424796 |
| Type | IDs |
|---|---|
| Synonymous | B27, C21orf61, FALP, FGD2, GCCD2 |
| Gene |
UniProtKB-ID:
MRAP_HUMAN
UniprotKB:
Q8TCY5
UniParc:
UPI000013E8CC,
UPI0000169C1A,
UPI000002A960,
UPI000012A4FF
EMBL:
AF483549,
AF454916,
BC062721,
AF454915,
AY079152
Ensembl:
ENSG00000170262
KO:
hsa:56246
|
| Nucleutide sequences |
EMBL-CDS:
AAL51048.1,
AAL80042.1,
AAL86908.1,
AAH62721.1,
AAL51049.1
Ensembl_TRS:
ENST00000303645,
ENST00000339944,
ENST00000399784
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000306697,
ENSP00000343661,
ENSP00000382684
RefSeq:
NP_848932.1,
XP_016883896.1,
NP_001366157.1,
NP_996781.1,
NP_001272323.1
|
| Others |
UniRef100:
UniRef100_Q8TCY5
UniRef90:
UniRef90_Q8TCY5
UniRef50:
UniRef50_Q8TCY5
UniGene:
Hs.584940
CCDS:
CCDS13612.1,
CCDS13613.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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