| Type | Description |
|---|---|
| Definition | beta-site APP-cleaving enzyme 2 |
| Date | Results | Publications |
|---|---|---|
| 2017-08-19 12:21:00 | The absence of BACE2 ameliorates glucose tolerance defects induced by IAPP overexpression in the beta-cell and promotes beta-cell survival. | 28337562 |
| 2013-09-07 11:56:00 | the BACE1 homologue BACE2 processes PMEL to generate functional amyloids. BACE2 is highly expressed in pigment cells and Bace2(-/-) but not Bace1(-/-) mice display coat color defects, implying a specific role for BACE2 during melanogenesis | 23754390 |
| 2013-06-08 10:27:00 | non-redundant roles of BACE1/2 in ectodomain shedding with BACE1 regulating a broader and BACE2 a more distinct set of beta-cell-enriched substrates including two proteins of the seizure 6 protein family (SEZ6L and SEZ6L2). | 23430253 |
| 2012-09-29 11:03:00 | Tmem27 dimerization is a dynamic process involving Bace2 | 22628310 |
| 2012-01-21 11:24:00 | Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. | 21907142 |
| Type | IDs |
|---|---|
| Synonymous | 1110059C24Rik, AEPLC, AI850424, ALP56, ARP1, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP |
| Gene |
UniProtKB-ID:
BACE2_MOUSE,
A0A0R4J0I8_MOUSE
UniprotKB:
Q9JL18,
A0A0R4J0I8
UniParc:
UPI000002673D,
UPI0000028B7A
EMBL:
AK052309,
AC164088,
AF216310,
AF051150,
AK165036,
BC131947,
AK078770,
CH466602,
BC120773
Ensembl:
ENSMUSG00000040605
KO:
mmu:56175
|
| Nucleutide sequences |
EMBL-CDS:
AAF36599.1,
AAD45964.1,
AAI20774.1,
BAE38011.1,
EDL03663.1,
BAC37384.1,
AAI31948.1,
BAC34931.1
Ensembl_TRS:
ENSMUST00000047275
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000043918
RefSeq:
NP_062390.3,
XP_006523131.1
|
| Others |
UniRef100:
UniRef100_A0A0R4J0I8,
UniRef100_Q9JL18
UniRef90:
UniRef90_Q9JL18
UniRef50:
UniRef50_Q9Y5Z0
UniGene:
Mm.97885
CCDS:
CCDS28359.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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