| Type | Description |
|---|---|
| Definition | ANKH inorganic pyrophosphate transport regulator |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:28:00 | Differences in intracellular localisation of ANKH mutants that relate to mechanisms of calcium pyrophosphate deposition disease and craniometaphyseal dysplasia. | 32366894 |
| 2020-07-18 10:30:00 | We used human vascular smooth muscle cells (VSMCs) and a rat model of chronic renal failure (CRF), and observed a native protective mechanism by which VC is reduced via the activation of Wnt1 and its transcriptional target ANKH inorganic pyrophosphate transport regulator (ANKH) gene | 31356809 |
| 2019-11-23 12:49:00 | ANK/ANKH protein carrying craniometaphyseal dysplasia mutations is present only at low levels due to rapid protein degradation. Decreased amounts of functional ANKH and improper subcellular localization are likely to contribute to CMD although these findings do not fully explain the pathogenic mechanisms seen in patients or the mouse model. | 30356088 |
| 2018-08-04 11:19:00 | Craniometaphyseal dysplasia mutations in ANKH diminish hiPSC differentiation into osteoclasts in vitro. | 29056330 |
| 2018-02-03 11:27:00 | our findings demonstrate that the miR-20a/ANKH axis mediates the stiff matrix- promoted CEP calcification, suggesting that miR-20a and ANKH are potential targets in restraining the progression of IDD. | 27142968 |
| Type | IDs |
|---|---|
| Synonymous | ANK, CCAL2, CMDJ, CPPDD, HANK, MANK, SLC62A1 |
| Gene |
UniProtKB-ID:
ANKH_HUMAN
UniprotKB:
Q9HCJ1
UniParc:
UPI000003F535,
UPI000015F3B5
EMBL:
AK315012,
AC016575,
BC009835,
CH471102,
BC014526,
AK001799,
AF274753,
AC010491,
AY358503,
AC025456,
AB046801
Ensembl:
ENSG00000154122
KO:
hsa:56172
|
| Nucleutide sequences |
EMBL-CDS:
EAX08034.1,
AAQ88867.1,
EAX08035.1,
AAF88039.1,
AAH14526.1,
BAB13407.1,
BAG37504.1,
BAG50976.1,
AAH09835.1
Gene_ORFName:
UNQ241/PRO274
Ensembl_TRS:
ENST00000284268
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000284268
RefSeq:
XP_016865133.1,
NP_473368.1,
XP_011512369.1
|
| Others |
UniRef100:
UniRef100_Q9HCJ1
UniRef90:
UniRef90_Q9HCJ1
UniRef50:
UniRef50_Q9HCJ1
UniGene:
Hs.156727
CCDS:
CCDS3885.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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