| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase 6 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-14 12:10:00 | Based on the experimentally determined models and parameters, dynamics of the p38alpha-MKK6-MKP5 system were explored, demonstrating for the first time that bistability can arise with this model at biologically feasible parameter values | 30663248 |
| 2019-09-21 10:14:00 | The loss of MKK6 protein diminishes p38 activation, leading to further degradation of the remaining TRIM9 in glioblastoma cells. The disruption of the TRIM9s-MKK6 mutual stabilization loop ultimately leads to the inactivation of p38 signaling and promotes tumor progression. | 29669288 |
| 2019-06-01 10:50:00 | Data suggest that mitogen-activated protein kinase kinase 6 (MAP2K6) might be an important regulator of leukemia inhibitory factor receptor (LIFR)-induced radioresistance in nasopharyngeal carcinoma cells (NPC). | 30245131 |
| 2019-04-06 10:50:00 | USP22 could interact directly with MKK6 promoter. Down-regulation of USP22 led to the decreased MKK6 mRNA expression | 30837379 |
| 2018-12-22 10:06:00 | Advanced glycation end products significantly activated ASK1, MKK3, and MKK6, which led to activation of p38 MAPK, resulting in upregulated fibrotic response in human coronary smooth muscle cells. | 30305582 |
| Type | IDs |
|---|---|
| Synonymous | MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3 |
| Gene |
UniProtKB-ID:
MP2K6_HUMAN,
A0A024R8K3_HUMAN,
A8K3Y2_HUMAN
UniprotKB:
P52564,
A0A024R8K3,
A8K3Y2
UniParc:
UPI000012F492,
UPI000002AE46
EMBL:
D87905,
U39656,
CH471099,
JX512448,
U39065,
U39064,
AK290747,
BC012009,
X96757,
U39657,
EU332850,
AB451376,
U49732
Ensembl:
ENSG00000108984
KO:
hsa:5608
|
| Nucleutide sequences |
EMBL-CDS:
AAC50389.1,
AAB03705.1,
BAA13496.1,
AAC50388.1,
CAA65532.1,
AAB05035.1,
AAH12009.1,
AAB03708.1,
EAW89084.1,
EAW89086.1,
BAG70190.1,
EAW89085.1,
BAF83436.1,
AGC09595.1,
ABY87539.1
Gene_ORFName:
hCG_28772,
hCG_28772
Ensembl_TRS:
ENST00000613873,
ENST00000589647,
ENST00000590474
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000468348,
ENSP00000467213,
ENSP00000477701
RefSeq:
XP_006722038.1,
NP_002749.2,
XP_011523329.1,
XP_011523328.1,
NP_001317379.1,
XP_005257573.1
|
| Others |
UniRef100:
UniRef100_P52564
UniRef90:
UniRef90_P52564
UniRef50:
UniRef50_P52564
UniGene:
Hs.463978
CCDS:
CCDS11686.1,
CCDS82194.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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