| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-03 12:55:00 | MEK2 is a critical modulating mechanism to down-regulate GCIP stability and function in cancer cells. | 31907980 |
| 2020-04-04 10:16:00 | USP21-mediated deubiquitination and stabilization of MEK2 plays a critical role in hepatocellular carcinoma development. | 29706623 |
| 2019-11-23 10:37:00 | Results indicate that some MEK1/2 mutations exert their function not only by their elevated intrinsic activity, but also by modulation of regulatory elements such as protein stability or dephosphorylation. | 30087384 |
| 2019-05-25 12:17:00 | MAP2K2 mutation is associated with cardio-facio-cutaneous syndrome. | 29799162 |
| 2018-11-03 11:55:00 | Here the authors identified a direct interaction of both MEK1 and MEK2 with AKT. The interaction between MEK and AKT affects cell migration and adhesion, but not proliferation. The specific mechanism of action of the MEK-AKT complex involves phosphorylation of the migration-related transcription factor FoxO1. | 28225038 |
| Type | IDs |
|---|---|
| Synonymous | CFC4, MAPKK2, MEK2, MKK2, PRKMK2 |
| Gene |
UniProtKB-ID:
MP2K2_HUMAN
UniprotKB:
P36507
UniParc:
UPI000012F489
EMBL:
BC000471,
BC018645,
L11285
Ensembl:
ENSG00000126934
KO:
hsa:5605
|
| Nucleutide sequences |
EMBL-CDS:
AAH18645.1,
AAH00471.1
Ensembl_TRS:
ENST00000262948
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000262948
RefSeq:
XP_006722862.1,
XP_016882479.1,
XP_016882478.1,
XP_016882480.1,
NP_109587.1
|
| Others |
UniRef100:
UniRef100_P36507
UniRef90:
UniRef90_P36507
UniRef50:
UniRef50_P36507
UniGene:
Hs.465627
CCDS:
CCDS12120.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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