| Type | Description |
|---|---|
| Definition | SAM domain and HD domain, 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:58:00 | Induction of Samhd1 by interferon gamma and lipopolysaccharide in murine macrophages requires IRF1. | 32270872 |
| 2020-07-04 11:47:00 | The phosphorylation of SAMHD1 in infected cells correlated with a reduced level of dNTP hydrolase activity and the loss of viral restriction. | 31548683 |
| 2018-09-01 11:20:00 | SAMHD1 inhibits NF-kappaB activation by interacting with NF-kappaB1/2 and reducing phosphorylation of the NF-kappaB inhibitory protein IkappaBalpha. SAMHD1 also interacts with the inhibitor-kappaB kinase epsilon (IKKepsilon) and IFN regulatory factor 7 (IRF7), leading to the suppression of the IFN-I induction pathway by reducing IKKepsilon-mediated IRF7 phosphorylation. SAMHD1 down-regulates innate immune responses to ... | 29610295 |
| 2018-08-18 12:05:00 | SAMHD1's restriction of dNTP supply enhances AID's mutagenicity and that the evolution of Ig hypermutation included the repurposing of antiviral mechanisms based on dNTP starvation. | 29669924 |
| 2018-03-24 10:33:00 | SAMHD1 crystal structure delineates the SAMHD1 allosteric activation process that governs SAMHD1 enzymatic activities. | 29379009 |
| Type | IDs |
|---|---|
| Synonymous | E330031J07Rik, Mg11, mSAMHD1 |
| Gene |
UniProtKB-ID:
SAMH1_MOUSE
UniprotKB:
Q60710
UniParc:
UPI00015DF5B1,
UPI0001857DED
EMBL:
U15635,
AK054490,
AK151335,
AL669828,
BC012721,
BC067198,
AK153390
Ensembl:
ENSMUSG00000027639
KO:
mmu:56045
|
| Nucleutide sequences |
EMBL-CDS:
BAC35801.1,
BAE31954.1,
BAE30313.1,
AAA66219.1,
AAH67198.1,
AAH12721.1
Ensembl_TRS:
ENSMUST00000057725,
ENSMUST00000088523
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000085880,
ENSMUSP00000059717
RefSeq:
NP_001357539.1,
NP_001132992.2,
NP_061339.4
|
| Others |
UniRef100:
UniRef100_Q60710
UniRef90:
UniRef90_Q60710
UniRef50:
UniRef50_Q9Y3Z3
UniGene:
Mm.248478,
Mm.468781
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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