| Type | Description |
|---|---|
| Definition | adherens junctions associated protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-30 11:44:00 | This study demonstrated that AJAP1 acted as a putative tumor suppressor while beta-catenin nuclear localization positively fed back on EGF/EGFR-attenuated AJAP1 expression in breast cancer, which might be beneficial to develop new therapeutic targets for decreasing nuclear beta-catenin-mediated malignancy in breast cancer. | 31171012 |
| 2018-06-09 11:20:00 | Stable overexpression of AJAP1 promotes adherence, decreases invasion of glioma cells through an extracellular-like matrix, and slows migration in the presence of laminin. These observations are reversed by gene knockdown using multiple siRNAs. Additionally, overexpression of AJAP1 decreases colony formation in glioma cells. | 29115565 |
| 2017-11-25 15:58:00 | AJAP1 blocked epithelial-to-mesenchymal transition by interacting with beta-catenin and inhibiting its nuclear translocation, which suppressed zinc finger E-box binding homeobox 1 (ZEB1) transcription. | 28383563 |
| 2017-09-30 11:39:00 | EGFR/EGFRvIII remodels the cytoskeleton via epigenetic silencing of AJAP1 in glioma cells. | 28634045 |
| 2016-10-08 12:21:00 | Reduced Expression of Associated Protein 1 is associated with Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy. | 26122373 |
| Type | IDs |
|---|---|
| Synonymous | MOT8, SHREW-1, SHREW1 |
| Gene |
UniProtKB-ID:
AJAP1_HUMAN
UniprotKB:
Q9UKB5
UniParc:
UPI00000728B8
EMBL:
Z98886,
AL049672,
AY282806,
AL023586,
AF175409,
AL391808,
AL049673
Ensembl:
ENSG00000196581
KO:
hsa:55966
|
| Nucleutide sequences |
EMBL-CDS:
AAP35025.1,
AAD53278.1,
CAB41246.1,
CAB41245.1
Ensembl_TRS:
ENST00000378190,
ENST00000378191
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000367433,
ENSP00000367432
RefSeq:
NP_061324.1,
XP_011540088.1,
NP_001035943.1,
XP_011540089.1
|
| Others |
UniRef100:
UniRef100_Q9UKB5
UniRef90:
UniRef90_Q9UKB5
UniRef50:
UniRef50_Q9UKB5
UniGene:
Hs.25924
CCDS:
CCDS54.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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