| Type | Description |
|---|---|
| Definition | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 12:34:00 | Findings highlight the crucial and specific role of CFTR in the immune control of M. abscessus by mounting effective oxidative responses. | 30759393 |
| 2020-04-11 10:36:00 | CFTR is involved in the regulation of Wnt-dependent hematopoiesis through its interaction with and regulation of the degradation process of a key adaptor protein of Wnt signaling, Dvl2. | 29449653 |
| 2020-03-07 10:44:00 | Described here is the chloride pathway of CFTR in atomic resolution for the first time. The results suggest that several intra- and extracellular entry sites may exist, no large conformational changes of the closed structures are required for opening and lipids may influence the channel path directly not only in an allosteric manner. | 31327045 |
| 2019-05-25 12:36:00 | data not only provide a reasonable explanation for the unexpected closed-state structure of phosphorylated E1372Q-zCFTR with a canonical ATP-bound dimer of the nucleotide binding domains (NBDs), but also implicate significant structural and functional differences between these two evolutionarily distant orthologs. | 30596737 |
| 2018-12-01 12:17:00 | study revealed an important role of cystic fibrosis transmembrane conductance regulator (CFTR) acting as an ion channel in regulating primordial germ cell migration during early embryogenesis | 29930176 |
| Type | IDs |
|---|---|
| Synonymous | si:dkey-270i2.2 |
| Gene |
UniProtKB-ID:
CFTR_DANRE
UniprotKB:
Q1LX78
UniParc:
UPI0000547B1A
EMBL:
BC171654,
BX470130
Ensembl:
ENSDARG00000041107
KO:
dre:559080
|
| Nucleutide sequences |
EMBL-CDS:
AAI71654.1
Ensembl_TRS:
ENSDART00000060243
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000060242
RefSeq:
NP_001038348.1
|
| Others |
UniRef100:
UniRef100_Q1LX78
UniRef90:
UniRef90_Q1LX78
UniRef50:
UniRef50_P13569
UniGene:
Dr.74099
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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