| Type | Description |
|---|---|
| Definition | mesoderm posterior bHLH transcription factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 12:04:00 | we demonstrate that upregulation of MESP1, a key tumor-promoting alteration, functions to create tumor dependency on an inbuilt lineage-survival process. MESP1, being the nodal point of this survival process, sustains the tumor dependency by transcriptionally activating key genes involved in tumor cell initiation, proliferation and progression including EMT | 31761621 |
| 2019-03-09 12:46:00 | Study demonstrates that while leaving primitive streak markers unaffected, MESP1 expression is required for timely vascular progenitor specification. Thus, MESP1 expression is essential for the molecular features of early CM, EC and VSMC lineage specification. | 30389344 |
| 2018-05-05 12:03:00 | The present study firstly provided experimental evidence supporting the concept that a MESP1 lossoffunction mutation may contribute to the development of double outlet right ventricle in humans, which presents a significant insight into the molecular pathogenesis of congenital heart disease. | 28677747 |
| 2017-01-28 10:32:00 | results suggest that pathologic variants in MESP1 may contribute to the development of congenital heart disease (CHD) and that additional protein partners and downstream targets could likewise contribute to the wide range of causes for CHD | 26694203 |
| 2015-09-26 19:57:00 | The MESP1-NKX2-5 hESC reporter line allows us to identify molecular cues crucial for specification and expansion of human cardiac mesoderm and early progenitors and their differentiation to specific cardiovascular derivatives. | 25187301 |
| Type | IDs |
|---|---|
| Synonymous | bHLHc5 |
| Gene |
UniProtKB-ID:
MESP1_HUMAN
UniprotKB:
Q9BRJ9
UniParc:
UPI0000070E08
EMBL:
BC006219,
AL357534,
AL357533
Ensembl:
ENSG00000166823
KO:
hsa:55897
|
| Nucleutide sequences |
EMBL-CDS:
CAB93425.1,
CAB93426.1,
AAH06219.1
Ensembl_TRS:
ENST00000300057
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000300057
RefSeq:
NP_061140.1
|
| Others |
UniRef100:
UniRef100_Q9BRJ9
UniRef90:
UniRef90_Q9BRJ9
UniRef50:
UniRef50_P97309
UniGene:
Hs.447531
CCDS:
CCDS10355.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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