| Type | Description |
|---|---|
| Definition | zinc finger protein 395 |
| Date | Results | Publications |
|---|---|---|
| 2018-06-16 10:55:00 | epigenomic profiling of clear cell renal cell carcinoma (ccRCC) establishes a compendium of somatically altered cis-regulatory elements, uncovering new potential targets including ZNF395. Loss of VHL, a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a and recruitment of histone acetyltransferase p300 at preexisting lineage-specific promoter-enhancer complexes | 28893800 |
| 2017-07-15 12:03:00 | The transcriptional activation of CXCL10 and CXCL11 by ZNF395 was abolished after inhibition of IKK by BMS-345541, which increased the stability of ZNF395. ZNF395 encodes at least two motifs that mediate the enhanced degradation of ZNF395 in response to IKK activation. Thus, IKK is required for ZNF395-mediated activation of transcription and enhances its turn-over to keep the activity of ZNF395 low. | 28316371 |
| 2014-11-08 13:13:00 | miR-525-3p promotes liver cancer cell migration and invasion by directly targeting ZNF395. | 24599008 |
| 2014-08-09 12:19:00 | IkBalpha kinase (IKK)-signaling is necessary to allow ZNF395 to activate transcription and simultaneously enhances its proteolytic degradation. | 24086395 |
| 2014-01-11 11:52:00 | Studies indicate that ZNF395 was strongly expressed in adipocytes, and suggest a role for ZNF395 as a modulator of adipogenesis. | 23760207 |
| Type | IDs |
|---|---|
| Synonymous | HDBP-2, HDBP2, HDRF-2, PBF, PRF-1, PRF1, Si-1-8-14 |
| Gene |
UniProtKB-ID:
ZN395_HUMAN,
Q7L9C8_HUMAN
UniprotKB:
Q9H8N7,
Q7L9C8
UniParc:
UPI0000073F08,
UPI0000049C21
EMBL:
AK312078,
CH471080,
AK023418,
AB044751,
AF263928,
BC001237,
AK002050,
AB044752,
AB073627,
AK098243,
AK026076,
AB057659,
AB044750
Ensembl:
ENSG00000186918
KO:
hsa:55893
|
| Nucleutide sequences |
EMBL-CDS:
BAA96783.1,
AAF73463.1,
BAA96785.1,
BAD29734.1,
BAB39851.1,
EAW63524.1,
EAW63523.1,
BAA96784.1,
EAW63522.1,
AAH01237.1,
EAW63519.1,
BAA92056.1,
EAW63521.1,
BAG53599.1,
BAB14571.1,
BAG35014.1,
BAB15352.1
Ensembl_TRS:
ENST00000523202,
ENST00000344423,
ENST00000523095
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000428452,
ENSP00000429640,
ENSP00000340494
RefSeq:
NP_061130.1
|
| Others |
UniRef100:
UniRef100_Q7L9C8,
UniRef100_Q9H8N7
UniRef90:
UniRef90_Q9H8N7,
UniRef90_Q7L9C8
UniRef50:
UniRef50_Q7L9C8,
UniRef50_Q9H8N7
UniGene:
Hs.435535,
Hs.695998
CCDS:
CCDS6067.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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