Type | Description |
---|---|
Definition | gasdermin B |
Date | Results | Publications |
---|---|---|
2020-07-18 10:42:00 | GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. | 30321352 |
2020-06-13 10:47:00 | this study demonstrated that GZMA from cytotoxic lymphocytes cleaves and activates GSDMB to induce target cell pyroptosis. | 32299851 |
2019-09-21 11:20:00 | Our study identified a functional asthma variant in the GSDMB gene of the 17q21 locus and implicates GSDMB-mediated epithelial cell pyroptosis in pathogenesis. | 29330013 |
2019-08-03 13:30:00 | we show that local CpG methylation mediates a proportion, but not all, of the functional effects of cis-acting asthma-susceptibility regulatory variants on GSDMB and ORMDL3 gene expression | 29374573 |
2018-12-22 11:55:00 | These results showed that the PBC susceptibility allele of rs12946510 disrupted the enhancer region for ORMDL3 and GSDMB gene expression (Fig. 6). Chromatin interaction between the sequence that contains rs12946510 and the upstream sequence of ORMDL3 and GSDMB also supported this enhancer model | 28588209 |
Type | IDs |
---|---|
Synonymous | GSDML, PP4052, PRO2521 |
Gene |
UniProtKB-ID:
GSDMB_HUMAN
UniprotKB:
Q8TAX9
UniParc:
UPI00000730AA,
UPI000013E0EA,
UPI0000200C24,
UPI000013EEC0,
UPI0000200C23,
UPI000004A0DB
EMBL:
AC090844,
BX538068,
AF119884,
AK000409,
BC025682,
AF258572,
CH471152,
AK296607
Ensembl:
ENSG00000073605
KO:
hsa:55876
|
Nucleutide sequences |
EMBL-CDS:
BAG59219.1,
AAG23775.1,
AAF69638.1,
AAH25682.1,
CAD97998.1,
BAA91146.1,
EAW60614.1
Gene_ORFName:
PRO2521,
PP4052
Ensembl_TRS:
ENST00000520542,
ENST00000418519,
ENST00000394179,
ENST00000394175,
ENST00000309481,
ENST00000360317
|
Protein sequencees |
Ensembl_PRO:
ENSP00000430157,
ENSP00000377729,
ENSP00000312584,
ENSP00000377733,
ENSP00000415049,
ENSP00000353465
RefSeq:
NP_061000.2,
NP_001375351.1,
NP_001159431.1,
NP_001159430.1,
NP_001375353.1,
NP_001356331.1,
NP_001375350.1,
NP_001375352.1,
NP_001035936.1,
NP_001375349.1
|
Others |
UniRef100:
UniRef100_Q8TAX9
UniRef90:
UniRef90_Q8TAX9
UniRef50:
UniRef50_Q8TAX9
UniGene:
Hs.306777
CCDS:
CCDS54119.1,
CCDS54120.1,
CCDS42313.1,
CCDS11354.1
|