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55876 GSDMB

55876

GSDMB

gasdermin B

protein-coding

Homo sapiens

基因描述

Type Description
Definition gasdermin B

研究结论

Date Results Publications
2020-07-18 10:42:00 GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. 30321352
2020-06-13 10:47:00 this study demonstrated that GZMA from cytotoxic lymphocytes cleaves and activates GSDMB to induce target cell pyroptosis. 32299851
2019-09-21 11:20:00 Our study identified a functional asthma variant in the GSDMB gene of the 17q21 locus and implicates GSDMB-mediated epithelial cell pyroptosis in pathogenesis. 29330013
2019-08-03 13:30:00 we show that local CpG methylation mediates a proportion, but not all, of the functional effects of cis-acting asthma-susceptibility regulatory variants on GSDMB and ORMDL3 gene expression 29374573
2018-12-22 11:55:00 These results showed that the PBC susceptibility allele of rs12946510 disrupted the enhancer region for ORMDL3 and GSDMB gene expression (Fig. 6). Chromatin interaction between the sequence that contains rs12946510 and the upstream sequence of ORMDL3 and GSDMB also supported this enhancer model 28588209

名称对应

Type IDs
Synonymous GSDML, PP4052, PRO2521
Gene
UniProtKB-ID: GSDMB_HUMAN
UniprotKB: Q8TAX9
UniParc: UPI00000730AA, UPI000013E0EA, UPI0000200C24, UPI000013EEC0, UPI0000200C23, UPI000004A0DB
EMBL: AC090844, BX538068, AF119884, AK000409, BC025682, AF258572, CH471152, AK296607
Ensembl: ENSG00000073605
KO: hsa:55876
Nucleutide sequences
EMBL-CDS: BAG59219.1, AAG23775.1, AAF69638.1, AAH25682.1, CAD97998.1, BAA91146.1, EAW60614.1
Gene_ORFName: PRO2521, PP4052
Ensembl_TRS: ENST00000520542, ENST00000418519, ENST00000394179, ENST00000394175, ENST00000309481, ENST00000360317
Protein sequencees
Ensembl_PRO: ENSP00000430157, ENSP00000377729, ENSP00000312584, ENSP00000377733, ENSP00000415049, ENSP00000353465
RefSeq: NP_061000.2, NP_001375351.1, NP_001159431.1, NP_001159430.1, NP_001375353.1, NP_001356331.1, NP_001375350.1, NP_001375352.1, NP_001035936.1, NP_001375349.1
Others
UniRef100: UniRef100_Q8TAX9
UniRef90: UniRef90_Q8TAX9
UniRef50: UniRef50_Q8TAX9
UniGene: Hs.306777
CCDS: CCDS54119.1, CCDS54120.1, CCDS42313.1, CCDS11354.1

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