| Type | Description |
|---|---|
| Definition | ASH1 like histone lysine methyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:53:00 | Novel role of ASH1L histone methyltransferase in anaplastic thyroid carcinoma. | 32398261 |
| 2020-12-12 13:24:00 | Mutations in ASH1L confer susceptibility to Tourette syndrome. | 31673123 |
| 2020-06-13 12:58:00 | ASH1L activation by MRG15 represents a delicate regulatory mechanism for how a cofactor activates an SET domain HMTase by releasing autoinhibition | 30827841 |
| 2020-06-13 12:58:00 | Ash1L stimulates H3K36 methyltransferase activity through Mrg15 binding | 30827843 |
| 2019-08-10 12:42:00 | Study shows that mutations associated with acute myelogenous leukemia (AML) result both in loss of miR-142-3p function and in decreased miR-142-5p expression. During hematopoietic maturation, loss of Mir142 increased ASH1L protein expression and consequently resulted in the aberrant maintenance of Hoxa gene expression in myeloid-committed hematopoietic progenitors. | 29724719 |
| Type | IDs |
|---|---|
| Synonymous | ASH1, ASH1L1, KMT2H, MRD52 |
| Gene |
UniProtKB-ID:
ASH1L_HUMAN
UniprotKB:
Q9NR48
UniParc:
UPI000013D5D2,
UPI0000DACAC8
EMBL:
AL139410,
DB282357,
AF257305,
AB209068,
AB037841,
AL353807
Ensembl:
ENSG00000116539
KO:
hsa:55870
|
| Nucleutide sequences |
EMBL-CDS:
BAA92658.1,
AAF68983.1,
BAD92305.1
Ensembl_TRS:
ENST00000368346,
ENST00000392403
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000357330,
ENSP00000376204
RefSeq:
XP_011508072.1,
XP_016857273.1,
XP_006711513.1,
XP_006711515.1,
NP_001353106.1,
XP_006711514.1,
NP_060959.2,
XP_016857277.1,
XP_016857274.1,
XP_016857275.1,
XP_011508071.1,
XP_005245394.1,
XP_016857276.1
|
| Others |
UniRef100:
UniRef100_Q9NR48
UniRef90:
UniRef90_Q9NR48
UniRef50:
UniRef50_Q9NR48
UniGene:
Hs.491060
CCDS:
CCDS1113.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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