| Type | Description |
|---|---|
| Definition | protein kinase N2 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-28 13:11:00 | Novel roles of PRK1 and PRK2 in cilia and cancer biology. | 32127582 |
| 2018-12-22 10:58:00 | The expression of PKN2 in colon cancer cells suppresses tumor associated M2 macrophage polarization and tumor growth. | 29368606 |
| 2018-01-13 12:02:00 | Steady-state kinetic analysis revealed that PKN1-3 follows a sequential ordered Bi-Bi kinetic mechanism, where peptide substrate binding is preceded by ATP binding. This kinetic mechanism was confirmed by additional kinetic studies for product inhibition and affinity of small molecule inhibitors. | 27919031 |
| 2017-10-14 12:53:00 | PKN2 knockdown in vitro decreased insulin-stimulated glucose uptake, incorporation into glycogen, and oxidation. Thus, PKN2 alters key signaling pathways and transcriptional networks to regulate glucose and lipid metabolism. | 28720584 |
| 2016-07-30 10:45:00 | Helicobacter pylori CagA interacts with PRK2 and inhibits its kinase activity. | 26041307 |
| Type | IDs |
|---|---|
| Synonymous | PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7 |
| Gene |
UniProtKB-ID:
PKN2_HUMAN
UniprotKB:
Q16513
UniParc:
UPI0002064FE3,
UPI0002064FE4,
UPI000004D291,
UPI0002064FDC,
UPI00017A7DA7
EMBL:
AL136381,
S75548,
CH471097,
AK298595,
AC119426,
AK300304,
BC125199,
U33052,
AK301066
Ensembl:
ENSG00000065243
KO:
hsa:5586
|
| Nucleutide sequences |
EMBL-CDS:
AAI25200.1,
AAB33346.1,
AAC50208.1,
BAG62673.1,
EAW73164.1,
BAG60783.1,
EAW73161.1,
BAG62057.1
Ensembl_TRS:
ENST00000370513,
ENST00000370521
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000359552,
ENSP00000359544
RefSeq:
NP_006247.1,
NP_001307637.1,
XP_016857272.1,
XP_016857271.1,
NP_001307636.1,
NP_001307638.1,
XP_011540074.1
|
| Others |
UniRef100:
UniRef100_Q16513
UniRef90:
UniRef90_Q16513
UniRef50:
UniRef50_Q16513
UniGene:
Hs.440833
CCDS:
CCDS81350.1,
CCDS714.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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