| Type | Description |
|---|---|
| Definition | centromere protein N |
| Date | Results | Publications |
|---|---|---|
| 2019-02-09 11:49:00 | CENP-N stabilizes CENP-A nucleosomes alone and additively with CENP-C in vitro. However, removal of CENP-C and CENP-N from cells, or mutating CENP-A so that it no longer interacts with CENP-C or CENP-N, had no effect on centromeric CENP-A stability in vivo. Thus, the stability of CENP-A nucleosomes in chromatin does not arise solely from its interactions with CENP-C or CENP-N. | 29343552 |
| 2018-08-25 11:48:00 | Collectively, these studies clarify how CENP-N and CENP-C decode and stabilize the non-canonical CENP-A nucleosome to enforce epigenetic centromere specification and kinetochore assembly. | 29280735 |
| 2018-05-05 10:58:00 | this study reports cryo-electron microscopy (cryo-EM), biophysical, biochemical, and cell biological studies of the interaction between the CENP-A nucleosome and CENP-N. | 29269420 |
| 2016-04-30 11:24:00 | Study demonstrate that the CENP-L-N complex plays a crucial role at the core of the 16-subunit Constitutive Centromere-Associated Network through interactions with CENP-C and CENP-H-I-KM. | 26698661 |
| 2012-04-07 11:28:00 | CENP-N is bound to kinetochores during S phase and G2, but is absent from kinetochores during mitosis and G1. | 22100916 |
| Type | IDs |
|---|---|
| Synonymous | BM039, C16orf60, CENP-N, ICEN32 |
| Gene |
UniProtKB-ID:
CENPN_HUMAN
UniprotKB:
Q96H22
UniParc:
UPI00001AEE0A,
UPI0001AE68AD,
UPI00001AECB9,
UPI0001AE68AE,
UPI000059D3C7
EMBL:
AK026313,
AK298554,
BC008972,
AK023669,
AF217515,
BC007334,
AC092718,
AK296024,
CH471114
Ensembl:
ENSG00000166451
KO:
hsa:55839
|
| Nucleutide sequences |
EMBL-CDS:
AAH07334.1,
AAF67626.1,
BAG51215.1,
BAG58793.1,
EAW95556.1,
EAW95553.1,
AAH08972.1,
BAG60749.1
Gene_ORFName:
BM-309
Ensembl_TRS:
ENST00000428963,
ENST00000305850,
ENST00000393335,
ENST00000299572,
ENST00000439957
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000305608,
ENSP00000299572,
ENSP00000395235,
ENSP00000393991,
ENSP00000377007
RefSeq:
NP_001094094.2,
NP_060925.2,
XP_006721299.1,
NP_001257403.1,
NP_001094095.2,
NP_001257402.1,
XP_016878945.1
|
| Others |
UniRef100:
UniRef100_Q96H22
UniRef90:
UniRef90_Q96H22
UniRef50:
UniRef50_Q96H22
UniGene:
Hs.726537
CCDS:
CCDS42199.1,
CCDS58483.1,
CCDS58482.1,
CCDS42200.1,
CCDS10931.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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