| Type | Description |
|---|---|
| Definition | centromere protein J |
| Date | Results | Publications |
|---|---|---|
| 2018-08-25 10:38:00 | CPAP regulates delivery of its bound beta-tubulin to define the size of microtubule-based cellular structures using a "clutch-like" mechanism. | 27306797 |
| 2018-07-21 10:52:00 | Data suggest that alcohol/ethanol exposure diminishes pool of proliferative neurons (Neuro2a cell line) through disordering of spindle orientation and promotion of asymmetric cell division; these neuronal abnormalities appear to be due to reduced CENPJ protein expression level. | 29778912 |
| 2016-12-24 10:14:00 | CPAP-S467D protein has a low affinity for microtubule binding but a high affinity for pericentriolar material proteins. | 26997271 |
| 2016-09-10 10:09:00 | CPAP promotes timely cilium disassembly to maintain neural progenitor pool. CPAP mutation causes Seckel syndrome with microcephaly. | 26929011 |
| 2016-08-27 12:10:00 | Data suggest that the single G-box domain (that appears to fold into 14-20 antiparallel beta-strands) of CENPJ has stable but dynamic structure; CRAP forms multimers (in solution and in crystals) of elongated fibrils similar to amyloid fibrils. [REVIEW] | 26517891 |
| Type | IDs |
|---|---|
| Synonymous | BM032, CENP-J, CPAP, LAP, LIP1, MCPH6, SASS4, SCKL4, Sas-4 |
| Gene |
UniProtKB-ID:
CENPJ_HUMAN,
F6VUX8_HUMAN,
A8K8P1_HUMAN
UniprotKB:
Q9HC77,
F6VUX8,
A8K8P1
UniParc:
UPI000013DC8A,
UPI00003FEDDA,
UPI0000488BCE,
UPI00015DA8F9
EMBL:
AJ303006,
AF139625,
BC113664,
BC113662,
BC024209,
CH471075,
AL354798,
AL833182,
BC113110,
AK292406,
AF141337
Ensembl:
ENSG00000151849
KO:
hsa:55835
|
| Nucleutide sequences |
EMBL-CDS:
AAI13111.1,
EAX08354.1,
AAI13663.1,
CAC80028.1,
AAG21074.1,
AAG49440.1,
CAI46195.1,
AAH24209.3,
AAI13665.1,
BAF85095.1
Ensembl_TRS:
ENST00000381884,
ENST00000616936,
ENST00000545981
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000371308,
ENSP00000477511,
ENSP00000441090
RefSeq:
XP_011533451.1,
NP_060921.3,
XP_011533452.1,
XP_016876162.1
|
| Others |
UniRef100:
UniRef100_F6VUX8,
UniRef100_Q9HC77,
UniRef100_A8K8P1
UniRef90:
UniRef90_Q9HC77-2,
UniRef90_Q9HC77
UniRef50:
UniRef50_Q9HC77
UniGene:
Hs.513379,
Hs.741581
CCDS:
CCDS9310.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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