| Type | Description |
|---|---|
| Definition | protein kinase C gamma |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 12:24:00 | Dominant negative mechanism due to truncated peptides produced by p.R76X underlies spinocerebellar ataxia type 14. inhibited phosphorylation activity and caused apoptosis in neurons. | 31158466 |
| 2019-08-31 13:09:00 | This study presented one of the largest SCA14 cohorts of patients reported contributing with novel variants and supporting the distinct phenotype spectrum with specific cellular defects resulting from different types of PRKCG mutations. | 29603387 |
| 2019-06-08 11:22:00 | This study demonstrated that a combination of both, loss-of-function and gain-of-function mechanisms are likely to underlie the pathogenesis of SCA14, caused by mutations in the C1 domain of | 30249303 |
| 2018-10-06 10:10:00 | This review showed that the Gamma signaling related genes and calcium signaling related genes then discuss their role for both Purkinje cell dendritic development and cerebellar ataxia. | 28554312 |
| 2018-06-23 12:02:00 | SUMOylation of EphB1 repressed activation of its downstream signaling molecule and consequently inhibited neuroblastoma tumorigenesis. | 29550816 |
| Type | IDs |
|---|---|
| Synonymous | PKC-gamma, PKCC, PKCG, PKCI(3), PKCgamma, SCA14 |
| Gene |
UniProtKB-ID:
KPCG_HUMAN,
B7Z3W6_HUMAN,
B2R5T1_HUMAN
UniprotKB:
P05129,
B7Z3W6,
B2R5T1
UniParc:
UPI0001914BA2,
UPI00017504D5,
UPI000000DC69,
UPI000191515F
EMBL:
AC008440,
M13977,
AK312302,
Z15114,
AF345987,
BC047876,
AK296434,
AK303741
Ensembl:
ENSG00000126583
KO:
hsa:5582
|
| Nucleutide sequences |
EMBL-CDS:
AAA60102.1,
CAA78820.1,
BAH14036.1,
AAH47876.1,
AAK13533.1,
BAH12352.1,
BAG35228.1
Ensembl_TRS:
ENST00000263431
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000263431
RefSeq:
NP_001303258.1,
NP_002730.1
|
| Others |
UniRef100:
UniRef100_B7Z3W6,
UniRef100_P05129,
UniRef100_B2R5T1
UniRef90:
UniRef90_P63318
UniRef50:
UniRef50_P63318
UniGene:
Hs.631564
CCDS:
CCDS12867.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员