| Type | Description |
|---|---|
| Definition | adenylate cyclase 10 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:14:00 | Soluble adenylyl cyclase links Ca(2+) entry to Ca(2+)/cAMP-response element binding protein (CREB) activation in vascular smooth muscle. | 31086231 |
| 2020-07-18 12:51:00 | Study provides the first report of a homozygous frameshift variation (c.1205_1206del; dbSNP rs779944215) in the exonic region of ADCY10 associated with recessive asthenozoospermia, in an inbred family from Iran. Noticeably, all relatives who were heterozygous or homozygous for the variant had a history of developing calcium kidney stones, confirming the association with absorptive hypercalciuria (OMIM#143870). | 31119281 |
| 2019-12-07 12:05:00 | the higher level of cyclic AMP observed in Parkin-mutant fibroblasts can contribute to a higher level of activity/expression by soluble adenylyl cyclase. | 30875974 |
| 2016-11-12 11:40:00 | results thus provide 1) novel insights into the communication between allosteric regulatory and active sites, 2) a novel mechanism for sAC inhibition, and 3) pharmacological compounds targeting this allosteric site and utilizing this mode of inhibition. | 26961873 |
| 2016-10-08 11:46:00 | The data support an important role for prostaglandin activation of sAC and in H2O2-induced barrier disruption. | 26857816 |
| Type | IDs |
|---|---|
| Synonymous | HCA2, HEL-S-7a, SAC, SACI, Sacy, hsAC |
| Gene |
UniProtKB-ID:
ADCYA_HUMAN,
A0A0K0K1J8_HUMAN
UniprotKB:
Q96PN6,
A0A0K0K1J8
UniParc:
UPI0001BDAB0D,
UPI0000470CA5,
UPI0000204D00,
UPI000006E3E2
EMBL:
BC117366,
AL035122,
CH471067,
AF271058,
AK302884,
AF299350,
Z97876,
GQ472219,
BC117372,
AF176813,
AF331033,
Z99943
Ensembl:
ENSG00000143199
KO:
hsa:55811
|
| Nucleutide sequences |
EMBL-CDS:
AAI17367.1,
BAG64062.1,
EAW90807.1,
AAL57036.1,
AAF74296.1,
EAW90804.1,
AAI17373.1,
AAF65931.1,
AAK96045.1,
CAA22684.1,
ACV87194.1
Ensembl_TRS:
ENST00000367848,
ENST00000367851,
ENST00000545172
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000356825,
ENSP00000441992,
ENSP00000356822
RefSeq:
NP_001284701.1,
XP_011508064.1,
XP_011508062.1,
XP_005245387.1,
XP_011508065.1,
XP_006711512.1,
NP_001161221.1,
XP_016857267.1,
XP_011508068.1,
NP_060887.2
|
| Others |
UniRef100:
UniRef100_Q96PN6
UniRef90:
UniRef90_Q96PN6
UniRef50:
UniRef50_Q96PN6
UniGene:
Hs.320892
CCDS:
CCDS72977.1,
CCDS53426.1,
CCDS1265.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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