| Type | Description |
|---|---|
| Definition | calcium voltage-gated channel auxiliary subunit alpha2delta 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 12:14:00 | CNS sensitisation was associated with a common genetic variant near the calcium channel gene CACNA2D3 at genome-wide significance. | 31378653 |
| 2020-06-06 11:15:00 | Results found that CACNA2D3 was lowly expressed in endometrial cancer (EC) tissues and cells. Its overexpression significantly blocked the tumor growth in an in vivo xenograft model while in vitro, it inhibited cell proliferation and migration, and promoted apoptosis and calcium influx. These data revealed that CACNA2D3 functions as a tumor suppressor in EC. | 31746409 |
| 2020-05-09 12:51:00 | The authors show that ventricular alpha2delta3 expression is low in healthy mice and humans, but significantly elevated in ventricular muscles from DM1 patients with conduction defects. | 31829940 |
| 2017-12-09 12:50:00 | Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 mutations, two each (6.3%) of CACNA2D3 and RASSF1 mutations, and one each (3.1%) of ATG7 and PLCD1 mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations. | 29122566 |
| 2017-09-09 10:24:00 | Findings demonstrate the tumor suppressive role of CACNA2D3 in gliomas. CACNA2D3 operates via Ca 2thorn signaling and the activation of non-canonical Wnt signaling to inhibit cell proliferation and motility and induce apoptosis. | 27583705 |
| Type | IDs |
|---|---|
| Synonymous | HSA272268 |
| Gene |
UniProtKB-ID:
CA2D3_HUMAN
UniprotKB:
Q8IZS8
UniParc:
UPI000004A7BF,
UPI0000072BC3,
UPI000006F4F2
EMBL:
BC137505,
BC137502,
AJ272213,
AJ272268,
AF516696
Ensembl:
ENSG00000157445
KO:
hsa:55799
|
| Nucleutide sequences |
EMBL-CDS:
CAB75878.1,
AAI37506.1,
AAN06673.1,
CAB75962.1,
AAI37503.1
Ensembl_TRS:
ENST00000620722,
ENST00000288197,
ENST00000474759,
ENST00000490478,
ENST00000471363,
ENST00000415676
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000418228,
ENSP00000288197,
ENSP00000417279,
ENSP00000389506,
ENSP00000419101,
ENSP00000478969
RefSeq:
NP_060868.2
|
| Others |
UniRef100:
UniRef100_Q8IZS8
UniRef90:
UniRef90_Q8IZS8
UniRef50:
UniRef50_Q8IZS8
UniGene:
Hs.656687
CCDS:
CCDS54598.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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