| Type | Description |
|---|---|
| Definition | lysine demethylase 4D |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:29:00 | Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression. | 32989255 |
| 2020-11-28 13:11:00 | Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling. | 32094404 |
| 2019-06-15 11:11:00 | KDM4D facilitates TLR4 transcription through demethylation of H3K9, thus activating TLR4/NF-kappaB signaling pathways in hepatic stellate cells, contributing to HSC activation and collagen crosslinking, further, hepatic fibrosis progression. | 30527625 |
| 2019-03-23 10:04:00 | Results demonstrate that KDM4D mRNA and protein levels are upregulated in gastrointestinal stromal tumour (GIST). Its overexpression strongly promotes GIST cell proliferation, migration, invasion and angiogenesis. In contrast, its silencing reduced cell proliferation, migration, invasion and tumor angiogenesis. More importantly, these effects mediated by KDM4D might be dependent on the Hif1beta/VEGFA signaling pathway. | 30060750 |
| 2018-04-14 10:36:00 | A high nuclear expression of KDM4D in samples of pancreatic resection margins significantly and independently predicted an earlier recurrence and could thus be used in the assessment of risk of relapse in clinical practice. | 29599352 |
| Type | IDs |
|---|---|
| Synonymous | JMJD2D |
| Gene |
UniProtKB-ID:
KDM4D_HUMAN
UniprotKB:
Q6B0I6
UniParc:
UPI00001A82EC
EMBL:
CH471065,
BC074739,
AL137545,
AK001113,
BC122858,
AP002383,
AK056162,
BC119010
Ensembl:
ENSG00000186280
KO:
hsa:55693
|
| Nucleutide sequences |
EMBL-CDS:
BAA91508.1,
CAB70803.1,
EAW66952.1,
AAI22859.1,
AAI19011.1,
AAH74739.1,
BAG51636.1
Ensembl_TRS:
ENST00000335080,
ENST00000536741,
ENST00000610872
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000482224,
ENSP00000460897,
ENSP00000334181
RefSeq:
NP_060509.2
|
| Others |
UniRef100:
UniRef100_Q6B0I6
UniRef90:
UniRef90_Q6B0I6
UniRef50:
UniRef50_Q6B0I6
UniGene:
Hs.503598
CCDS:
CCDS8302.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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