| Type | Description |
|---|---|
| Definition | Ly1 antibody reactive |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 11:50:00 | Ly1 antibody reactive cell growth-regulating nucleolar protein (LYAR) expression is induced by beta interferon (IFN-beta) during virus infection. LYAR interacts with phosphorylated IFN regulatory factor 3 (IRF3) to impede the DNA binding capacity of IRF3, thereby suppressing the transcription of IFN-beta and downstream IFN-stimulated genes (ISGs). LYAR is a repressor of host innate immune responses to promote virus rep... | 31413131 |
| 2019-12-14 12:04:00 | These data suggest that LYAR promotes the association of the BRD2-KAT7 and BRD4-KAT7 complexes with transcription-competent rDNA loci but not to transcriptionally silent rDNA loci, thereby increasing rRNA synthesis by altering the local acetylation status of histone H3 and H4. | 31504794 |
| 2018-05-12 12:02:00 | Data suggest that LYAR induces proliferation and promotes survival of neuroblastoma cells by repressing the expression of oxidative stress genes such as CHAC1 and suppressing oxidative stress, and identify LYAR as a novel co-factor in N-Myc oncogenesis. | 28686580 |
| 2016-08-13 10:50:00 | LYAR may promote tumor cell migration and invasion by upregulating galectin-1 gene expression in colorectal cancer. | 26413750 |
| 2015-10-31 10:34:00 | Results show that LYAR protein expression is testis-predominant but can also be found in cancer cells originated from tissues other than testis. Lyar seems to promote proliferation of NIH-3T3 cells. | 24990247 |
| Type | IDs |
|---|---|
| Synonymous | ZC2HC2, ZLYAR |
| Gene |
UniProtKB-ID:
LYAR_HUMAN
UniprotKB:
Q9NX58
UniParc:
UPI00001AE9B6
EMBL:
CR533548,
AF229835,
BC015796,
AK000432,
CH471131,
AL136750
Ensembl:
ENSG00000145220
KO:
hsa:55646
|
| Nucleutide sequences |
EMBL-CDS:
AAF42870.1,
CAG38579.1,
EAW82439.1,
BAA91162.1,
EAW82438.1,
CAB66684.1,
AAH15796.1,
EAW82437.1
Gene_ORFName:
PNAS-5
Ensembl_TRS:
ENST00000343470,
ENST00000452476
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000345917,
ENSP00000397367
RefSeq:
XP_011511807.1,
XP_011511808.1,
NP_001139197.1,
NP_060286.1
|
| Others |
UniRef100:
UniRef100_Q9NX58
UniRef90:
UniRef90_Q9NX58
UniRef50:
UniRef50_Q9NX58
UniGene:
Hs.425427
CCDS:
CCDS3374.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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