| Type | Description |
|---|---|
| Definition | solute carrier family 39 member 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 13:03:00 | Elucidating the H(+) Coupled Zn(2+) Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica. | 31979155 |
| 2020-08-29 12:46:00 | Analysis of the relationship between the mutation site of the SLC39A4 gene and acrodermatitis enteropathica by reporting a rare Chinese twin: a case report and review of the literature. | 31987033 |
| 2020-07-18 12:15:00 | High ZIP4 expression was associated with metastasis and poor prognosis in human nasopharyngeal carcinoma patients. Elevated ZIP4 expression induced the EMT in C666-1 cells by activating the PI3K/Akt pathway. Downregulation of ZIP4 expression enhanced the radiosensitivity of C666-1 cells and inhibited metastasis. | 31383854 |
| 2020-07-18 10:30:00 | This work provides important insights into the transport mechanism of the ZIPs broadly involved in transition metal homeostasis and signaling, and also a paradigm on a novel function of metal cluster in metalloproteins. | 31914589 |
| 2020-04-11 12:41:00 | We found that ZIP4 overexpression enhanced cell growth and chemoresistance in pancreatic cancer cells, whereas knockdown of ZIP4 reduced metastasis and sensitized pancreatic cancer cells to chemotherapy. We also found that ZIP4 increases expression of the transcription factor ZEB1, which activates expression of ITGA3 and ITGB1. | 31711924 |
| Type | IDs |
|---|---|
| Synonymous | AEZ, AWMS2, ZIP4 |
| Gene |
UniProtKB-ID:
S39A4_HUMAN,
Q9NX22_HUMAN
UniprotKB:
Q6P5W5,
Q9NX22
UniParc:
UPI0002064DC5,
UPI0002064DC4,
UPI0000071457
EMBL:
BC001688,
AK025537,
AK000334,
AF205589,
BC062625,
AK000489
Ensembl:
ENSG00000147804
KO:
hsa:55630
|
| Nucleutide sequences |
EMBL-CDS:
BAB15164.1,
BAA91091.1,
AAH01688.2,
AAH62625.1,
BAA91200.1
Ensembl_TRS:
ENST00000301305,
ENST00000276833
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000301305,
ENSP00000276833
RefSeq:
NP_570901.3,
NP_060237.3,
NP_001361768.1,
NP_001267486.1,
XP_024302957.1
|
| Others |
UniRef100:
UniRef100_Q6P5W5
UniRef90:
UniRef90_Q6P5W5
UniRef50:
UniRef50_Q6P5W5
UniGene:
Hs.521934
CCDS:
CCDS6424.1,
CCDS43782.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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