| Type | Description |
|---|---|
| Definition | protein kinase AMP-activated catalytic subunit alpha 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:44:00 | RSK2 protects human breast cancer cells under endoplasmic reticulum stress through activating AMPKalpha2-mediated autophagy. | 32958832 |
| 2019-10-26 10:48:00 | activation increased the expression and nuclear localization of Twist1 which regulated epithelial-mesenchymal transition. | 29950484 |
| 2019-10-19 11:35:00 | Mechanistically, AMP-activated protein kinase (AMPK)-mediated phosphorylation of BECN1 at Ser90/93/96 is required for BECN1-SLC7A11 complex formation and lipid peroxidation. | 30057310 |
| 2019-05-25 10:42:00 | A double-negative feedback loop between Akt and AMPK controls the switch between matrix-attached and matrix-detached states needed to coordinate cell growth and survival during breast cancer metastasis. | 29339542 |
| 2018-10-20 10:38:00 | It is an intracellular central metabolic sensor as well as a regulator, has been demonstrated to play significant roles in the contracting skeletal muscles, suggesting that AMPK should be one of the key molecules mediating metabolic effects during physical exercise. | 30270274 |
| Type | IDs |
|---|---|
| Synonymous | AMPK, AMPK2, AMPKa2, PRKAA |
| Gene |
UniProtKB-ID:
AAPK2_HUMAN
UniprotKB:
P54646
UniParc:
UPI00001250A9
EMBL:
U06454,
BC069740,
BC069823,
AL035705,
BC069680
Ensembl:
ENSG00000162409
KO:
hsa:5563
|
| Nucleutide sequences |
EMBL-CDS:
AAA64745.1,
AAH69740.1,
AAH69823.1,
AAH69680.1
Ensembl_TRS:
ENST00000371244
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360290
RefSeq:
XP_016857183.1,
XP_016857182.1,
XP_016857181.1,
NP_006243.2
|
| Others |
UniRef100:
UniRef100_P54646
UniRef90:
UniRef90_P54646
UniRef50:
UniRef50_P54646
UniGene:
Hs.437039
CCDS:
CCDS605.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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