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55617 TASP1

55617

TASP1

taspase 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition taspase 1

研究结论

Date Results Publications
2019-10-26 10:22:00 TASP1 is a novel disease-related gene that is associated with a disease phenotype overlapping with Wiedemann-Steiner syndrome as both are caused by defects in the same pathway. 29633245
2019-09-14 10:32:00 Taspase 1 processing promotes TFIIA's nuclear accumulation by evolutionary conserved nuclear export signal (NES, amino acids 21VINDVRDIFL30) masking, and modulates its transcriptional activity. 28992066
2019-07-20 11:52:00 Proteolytic processing of TFIIA by Taspase1 was found to mask evolutionary conserved nuclear export signal, thereby promoting nuclear localization and transcriptional activation of TFIIA target genes, such as CDKN2A. 29097782
2017-09-16 10:47:00 Studies indicate that threonine Aspartase1 (Taspase1) is overexpressed in numerous liquid and solid malignancies and was characterized as a 'non-oncogene addiction' protease. 26657154
2016-08-13 10:07:00 simultaneous expression of the leukemogenic AF4-MLL and dnTASP1 causes the disappearance of the leukemogenic oncoprotein, because the uncleaved AF4-MLL protein (328 kDa) is subject to proteasomal degradation. 26137584

名称对应

Type IDs
Synonymous C20orf13, dJ585I14.2
Gene
UniProtKB-ID: TASP1_HUMAN
UniprotKB: Q9H6P5
UniParc: UPI0001915370, UPI00000382E5, UPI0001914DE0
EMBL: AK304488, BC025266, AL121782, AL133463, AK025671, AK299940, AL121754, AK316311, AK000219, AL050320, AL158089
Ensembl: ENSG00000089123
KO: hsa:55617
Nucleutide sequences
EMBL-CDS: BAH14682.1, BAA91018.1, AAH25266.1, BAH13176.1, BAB15209.1, BAH14199.1
Ensembl_TRS: ENST00000337743
Protein sequencees
Ensembl_PRO: ENSP00000338624
RefSeq: XP_011527594.1, NP_001310532.1, XP_016883419.1, XP_016883416.1, XP_016883417.1, NP_060184.2, NP_001310531.1, XP_016883420.1, XP_016883418.1, XP_011527596.1, NP_001310533.1
Others
UniRef100: UniRef100_Q9H6P5
UniRef90: UniRef90_Q9H6P5
UniRef50: UniRef50_Q9H6P5
UniGene: Hs.348297
CCDS: CCDS13116.1

全选

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