| Type | Description |
|---|---|
| Definition | FAD dependent oxidoreductase domain containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-05-16 09:38:00 | Results show that depletion of FOXRED1 in myoblasts results in decreased levels of fully assembled complexes I and II. FOXRED1 associates with the ND1-containing subcomplexes of ~370 kDa and ~620 kDa and that FOXRED1 activity is required for the formation of a 550-kDa subcomplex of complex I. | 27215383 |
| 2016-06-04 10:12:00 | Loss of FOXRED1, coupled with protein, choline and/or folate-deficient diets results in the depletion of glutathione, the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I. | 26235939 |
| 2016-02-13 10:58:00 | A structural model of FOXRED1 reveals a large substrate-binding cavity and a putative oxygen-binding site. | 25765152 |
| 2016-01-30 11:33:00 | FOXRED1 is a crucial component in the productive assembly of respiratory chain complex I and that mutations in FOXRED1 leading to partial loss of function cause defects in complex I biogenesis. | 25678554 |
| 2010-12-14 07:41:00 | Mutations in FOXRED1 are associated with complex I deficiency. | 20818383 |
| Type | IDs |
|---|---|
| Synonymous | FP634, H17, MC1DN19 |
| Gene |
UniProtKB-ID:
FXRD1_HUMAN,
B4DXM1_HUMAN
UniprotKB:
Q96CU9,
B4DXM1
UniParc:
UPI0000034DF9,
UPI0000ED8F6A,
UPI00017A70AD,
UPI0000037C04
EMBL:
BC013902,
AK295267,
AK302039,
AK023987,
AL136923,
BC002910,
AF103801,
CH471065,
AF447877
Ensembl:
ENSG00000110074
KO:
hsa:55572
|
| Nucleutide sequences |
EMBL-CDS:
EAW67683.1,
AAF02421.1,
CAB66857.1,
AAH02910.2,
AAH13902.1,
BAG58254.1,
BAG51246.1,
AAQ04652.1,
BAG63433.1
Gene_ORFName:
FP634
Ensembl_TRS:
ENST00000263578,
ENST00000532125
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000434178,
ENSP00000263578
RefSeq:
XP_006718944.1,
XP_011541198.1,
XP_016873490.1,
XP_016873493.1,
XP_006718942.1,
XP_016873489.1,
XP_016873494.1,
XP_016873491.1,
NP_060017.1,
XP_011541197.1,
XP_016873492.1,
XP_016873495.1
|
| Others |
UniRef100:
UniRef100_Q96CU9
UniRef90:
UniRef90_Q96CU9
UniRef50:
UniRef50_Q96CU9
UniGene:
Hs.317190
CCDS:
CCDS8471.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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