| Type | Description |
|---|---|
| Definition | interleukin 17 receptor B |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 12:26:00 | IL17RB predicts the prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer. | 31585811 |
| 2020-04-18 11:10:00 | Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer. | 30945288 |
| 2020-04-11 10:46:00 | Using CRISPR-Cas9-mediated IL17RB-CreERT2 knockin human organoids, study showed that IL17RB marks human colorectal cancer stem cells by lineage tracing, and that long-term targeting of IL17RB+ cells strongly suppressed the tumor growth in vivo. This study identifies IL17RB+ cancer stem cells and preclinically validates them as a cancer therapeutic target. | 31182574 |
| 2019-08-03 10:12:00 | As the ligase activity of CRL4Cdt2 depends on proliferating cell nuclear antigen (PCNA) loading onto DNA, the present results suggest that the DNA-binding domain facilitates the CRL4Cdt2-mediated recognition and ubiquitination of substrates bound to PCNA on chromatin. | 30649446 |
| 2019-05-18 11:08:00 | IL-17RB was up-regulated in lung cancer tissue and associated with lymph node metastasis and distant metastasis, as well as poor patient survival. 17RB activation is required for IL-17B-mediated ERK phosphorylation. | 29496538 |
| Type | IDs |
|---|---|
| Synonymous | CRL4, EVI27, IL17BR, IL17RH1 |
| Gene |
UniProtKB-ID:
I17RB_HUMAN
UniprotKB:
Q9NRM6
UniParc:
UPI0000038A0B,
UPI000002AB7B
EMBL:
AF212365,
AY359122,
AF208110,
AF250309,
BC000980,
AF208111,
AY518533
Ensembl:
ENSG00000056736
KO:
hsa:55540
|
| Nucleutide sequences |
EMBL-CDS:
AAK37428.1,
AAF86051.1,
AAR89910.1,
AAF78776.1,
AAH00980.1,
AAQ89956.1,
AAF86052.1
Gene_ORFName:
UNQ2501/PRO19612
Ensembl_TRS:
ENST00000288167
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000288167
RefSeq:
XP_005265367.1,
XP_016862295.1,
XP_016862294.1,
XP_024309403.1,
XP_016862293.1,
XP_011532243.1,
XP_024309402.1,
NP_061195.2,
XP_024309404.1,
XP_005265369.1,
XP_016862296.1,
XP_005265368.1
|
| Others |
UniRef100:
UniRef100_Q9NRM6
UniRef90:
UniRef90_Q9NRM6
UniRef50:
UniRef50_Q9NRM6
UniGene:
Hs.654970
CCDS:
CCDS2874.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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