| Type | Description |
|---|---|
| Definition | sphingomyelin phosphodiesterase 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 11:25:00 | demonstrate that PS binding at the N-terminal and juxtamembrane regions of nSMase2 rather acts as a conformational switch leading to interdomain interactions that are critical to enzyme activation | 30890560 |
| 2019-10-19 11:39:00 | Compounds against human nSMase2 we identified. | 30531925 |
| 2019-06-15 12:16:00 | These findings identify neutral sphingomyelinase 2 as essential in TCR signaling when dynamic cytoskeletal reorganization promotes continued lateral and vertical supply of TCR signaling components | 29720981 |
| 2019-05-11 10:50:00 | REVIEW: studies adressing the role of NSM2 in T cell polarity in which the enzyme plays a major role in regulating cytoskeletal dynamics. | 29337691 |
| 2018-06-16 10:19:00 | the DK switch regulates ceramide generation by nSMase2 and is governed by an allosteric interdomain interaction at the membrane interface | 28652336 |
| Type | IDs |
|---|---|
| Synonymous | NSMASE2 |
| Gene |
UniProtKB-ID:
NSMA2_HUMAN,
A8K0T6_HUMAN
UniprotKB:
Q9NY59,
A8K0T6
UniParc:
UPI0000037769,
UPI00015DA563,
UPI000189A7EE
EMBL:
BC143631,
BC112238,
AC099521,
AJ250460,
AK289651
Ensembl:
ENSG00000103056
KO:
hsa:55512
|
| Nucleutide sequences |
EMBL-CDS:
CAB92964.1,
AAI43632.1,
AAI12239.1,
BAF82340.1
Ensembl_TRS:
ENST00000219334,
ENST00000563226
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000219334,
ENSP00000455955
RefSeq:
XP_016878895.1,
XP_005256089.1,
XP_011521509.1,
XP_016878894.1,
NP_061137.1,
XP_016878896.1,
XP_011521512.1,
XP_011521510.1,
XP_016878897.1,
XP_005256088.1,
XP_011521511.1
|
| Others |
UniRef100:
UniRef100_Q9NY59,
UniRef100_A8K0T6
UniRef90:
UniRef90_Q9NY59
UniRef50:
UniRef50_Q9JJY3
UniGene:
Hs.368421
CCDS:
CCDS10867.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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