| Type | Description |
|---|---|
| Definition | YOD1 deubiquitinase |
| Date | Results | Publications |
|---|---|---|
| 2020-01-04 11:33:00 | findings thus provided novel insights into the regulatory cascade of the cellular antiviral response through YOD1-mediated K63-linked deubiquitination and aggregation of MAVS. | 30952814 |
| 2019-01-26 11:46:00 | YOD1 may inhibit cell proliferation and migration associated with the pathogenesis of NSCL/P through TGF-beta3 signaling. The study indicates a novel role of YOD1 in regulating TGF-beta3 signaling to affect cell proliferation and migration resulting in cleft lip with or without cleft palate. | 30345304 |
| 2018-11-10 10:14:00 | This study showed that YOD1 overexpression enhances cell migration by promoting TGF-beta3 signaling which may play an important role in lip and palate formation. | 30145984 |
| 2018-04-28 10:16:00 | Mechanistically, YOD1 deubiquitinates ITCH, an E3 ligase of LATS, and enhances the stability of ITCH, which leads to reduced levels of LATS and a subsequent increase in the YAP/TAZ level. | 28416659 |
| 2018-03-31 10:29:00 | Data suggest that YOD1 is a novel regulator of the Hippo pathway, and thereby a potential therapeutic target for liver cancer. | 28502290 |
| Type | IDs |
|---|---|
| Synonymous | DUBA8, OTUD2, PRO0907 |
| Gene |
UniProtKB-ID:
OTU1_HUMAN
UniprotKB:
Q5VVQ6
UniParc:
UPI000022B22C,
UPI0000458A05
EMBL:
AL445493,
AF116608,
BC137167,
CH471100,
AK128014,
AL833081,
BC137166
Ensembl:
ENSG00000180667
KO:
hsa:55432
|
| Nucleutide sequences |
EMBL-CDS:
AAF71033.1,
AAI37167.1,
EAW93510.1,
EAW93509.1,
BAC87233.1,
AAI37168.1,
CAD89975.1
Gene_ORFName:
PRO0907
Ensembl_TRS:
ENST00000315927,
ENST00000367084
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000326813,
ENSP00000356051
RefSeq:
NP_001263249.1,
NP_061036.3
|
| Others |
UniRef100:
UniRef100_Q5VVQ6
UniRef90:
UniRef90_Q5VVQ6
UniRef50:
UniRef50_Q5VVQ6
UniGene:
Hs.567533,
Hs.745490
CCDS:
CCDS31002.1,
CCDS60402.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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