| Type | Description |
|---|---|
| Definition | signal regulatory protein gamma |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:12:00 | Altered expression of SIRPgamma on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells. | 32853219 |
| 2019-11-09 11:54:00 | The SNP rs2281808 TT variant reduced SIRPgamma expression on T-cells. SIRPgamma(low) CD8 T-cells in CT and TT individuals were in a heightened effector state with lower activation threshold and had greater gene expression of molecules associated with migratory and cytotoxic potential. SIRPgamma(low) CD8 T-cells were deficient in transcription factors associated with long-term functional memory formation. | 30337675 |
| 2015-04-04 12:59:00 | SIRPgamma in complex with FabOX117 forms a dimer in the crystal. Binding to the Fab fixes the position of domain 1 relative to domains 2/3 exposing a surface which favours formation of a homotypic dimer. | 23826770 |
| 2014-08-23 11:19:00 | The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG. | 24162948 |
| 2010-01-21 00:00:00 | tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) and signal regulatory protein, gamma (SIRPG) appear to contribute to gender difference in incidence of systemic lupus erythematosus. | 19473566 |
| Type | IDs |
|---|---|
| Synonymous | CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1 |
| Gene |
UniProtKB-ID:
SIRPG_HUMAN
UniprotKB:
Q9P1W8
UniParc:
UPI000049B155,
UPI00001833CA,
UPI00001AE5FD,
UPI0000073753
EMBL:
AL138804,
AY748247,
CH471133,
BC064532,
AL109809,
AB042624,
AY748248,
BC020629
Ensembl:
ENSG00000089012
KO:
hsa:55423
|
| Nucleutide sequences |
EMBL-CDS:
BAA95692.1,
AAV88531.1,
EAX10616.1,
AAH64532.1,
AAV88530.1,
AAH20629.2
Ensembl_TRS:
ENST00000303415,
ENST00000216927,
ENST00000381580,
ENST00000344103,
ENST00000381583
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000370992,
ENSP00000370995,
ENSP00000216927,
ENSP00000342759,
ENSP00000305529
RefSeq:
XP_011527589.1,
XP_005260806.1,
NP_001034597.1,
NP_061026.2,
XP_011527588.1,
NP_543006.2
|
| Others |
UniRef100:
UniRef100_Q9P1W8
UniRef90:
UniRef90_Q9P1W8
UniRef50:
UniRef50_Q9P1W8
UniGene:
Hs.590883
CCDS:
CCDS33434.1,
CCDS13021.2,
CCDS13020.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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