| Type | Description |
|---|---|
| Definition | p53-induced death domain protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 13:56:00 | PIDD interaction with KEAP1 as a new mutation-independent mechanism to promote NRF2 stabilization and chemoresistance in NSCLC. | 31455821 |
| 2020-07-18 10:29:00 | Attention-deficit/hyperactivity disorder risk alleles correlated with increased expression (and decreased methylation) of ARTN and PIDD1 and with a decreased expression (and increased methylation) of C2orf82. | 31582733 |
| 2017-12-02 11:39:00 | Whole exome sequencing (WES) of an affected fetus, and subsequent Sanger sequencing of the second fetus, revealed a homozygous frameshift variant in CRADD, which encodes an adaptor protein that interacts with PIDD and caspase-2 to initiate apoptosis | 28686357 |
| 2017-09-16 11:13:00 | NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 activation cascade. | 28432080 |
| 2017-02-18 10:14:00 | PIDD expression was lower in HCC tissues and HCC cell lines, compared with the adjacent non-tumorous tissues and LO2 normal hepatocytes. PIDD could serve as an independent prognostic factor to predict the survival of HCC patients. PIDD facilitated cell cycle progression and accelerated cell proliferation in HepG2 cells, while overexpression of PIDD resulted in cell cycle arrest at G1 phase in Hep3B cells. | 26846109 |
| Type | IDs |
|---|---|
| Synonymous | LRDD, PIDD |
| Gene |
UniProtKB-ID:
PIDD1_HUMAN
UniprotKB:
Q9HB75
UniParc:
UPI00004EC289,
UPI0000E44579,
UPI0000E44578,
UPI0000DA5A02,
UPI00004EC288,
UPI000045644A,
UPI0000E44577
EMBL:
AB208949,
BC014904,
AF274972,
AF229178,
AB208832,
AF465246,
AK074893,
AB209529,
AL833849
Ensembl:
ENSG00000177595
KO:
hsa:55367
|
| Nucleutide sequences |
EMBL-CDS:
AAH14904.1,
BAD92766.1,
BAD92069.1,
AAP97716.1,
BAD92186.1,
AAG13461.1,
AAF69491.1,
BAC11272.1,
CAD38708.1
Ensembl_TRS:
ENST00000347755,
ENST00000411829
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000416801,
ENSP00000337797
RefSeq:
XP_011518513.1,
XP_005253064.1,
XP_005253062.1,
XP_011518512.1,
XP_005253065.1,
XP_005253063.1,
XP_016873482.1,
NP_665893.2,
XP_011518511.1,
XP_011518515.1,
XP_011518514.1,
NP_665894.2
|
| Others |
UniRef100:
UniRef100_Q9HB75
UniRef90:
UniRef90_Q9HB75
UniRef50:
UniRef50_Q9HB75
UniGene:
Hs.592290
CCDS:
CCDS44508.1,
CCDS7716.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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