six6b - SIX homeobox 6b-BMKCloudï½ç¾è¿å®¢äº

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553611 six6b

基因描述

Type	Description
Definition	SIX homeobox 6b

研究结论

Date	Results	Publications
2017-09-23 10:30:00	We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a	28073927

名称对应

Type	IDs
Synonymous	si:dkey-225h23.3, zgc:110344
Gene	UniProtKB-ID: Q5TYZ2_DANRE UniprotKB: Q5TYZ2 UniParc: UPI0000454813 EMBL: BX649231, BC095226 Ensembl: ENSDARG00000031316 KO: dre:553611
Nucleutide sequences	EMBL-CDS: AAH95226.1 Ensembl_TRS: ENSDART00000125039
Protein sequencees	Ensembl_PRO: ENSDARP00000110487 RefSeq: NP_001018421.1
Others	UniRef100: UniRef100_Q5TYZ2 UniRef90: UniRef90_Q5TYZ2 UniRef50: UniRef50_A0A2R9A339 UniGene: Dr.82855

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
30765521	Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish. Proc Natl Acad Sci U S A Yohey Ogawa , Tomoya Shiraki , Yoshimasa Asano , Akira Muto , Koichi Kawakami , Yutaka Suzuki , Daisuke Kojima , Yoshitaka Fukada	2019-03-05	-
28073927	New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Hum. Mol. Genet. HenriÃ«t Springelkamp , Adriana I Iglesias , Aniket Mishra , RenÃ© HÃ¶hn , Robert Wojciechowski , Anthony P Khawaja , Abhishek Nag , Ya Xing Wang , Jie Jin Wang , Gabriel Cuellar-Partida , Jane Gibson , Jessica N Cooke Bailey , Eranga N Vithana , Puya Gharahkhani , Thibaud Boutin , Wishal D Ramdas , Tanja Zeller , Robert N Luben , Ekaterina Yonova-Doing , Ananth C Viswanathan , Seyhan Yazar , Angela J Cree , Jonathan L Haines , Jia Yu Koh , Emmanuelle Souzeau , James F Wilson , Najaf Amin , Christian MÃ¼ller , Cristina Venturini , Lisa S Kearns , Jae Hee Kang , NEIGHBORHOOD Consortium , Yih Chung Tham , Tiger Zhou , Elisabeth M van Leeuwen , Stefan Nickels , Paul Sanfilippo , Jiemin Liao , Herma van der Linde , Wanting Zhao , Leonieke M E van Koolwijk , Li Zheng , Fernando Rivadeneira , Mani Baskaran , Sven J van der Lee , Shamira Perera , Paulus T V M de Jong , Ben A Oostra , AndrÃ© G Uitterlinden , Qiao Fan , Albert Hofman , E-Shyong Tai , Johannes R Vingerling , Xueling Sim , Roger C W Wolfs , Yik Ying Teo , Hans G Lemij , Chiea Chuen Khor , Rob Willemsen , Karl J Lackner , Tin Aung , Nomdo M Jansonius , Grant Montgomery , Philipp S Wild , Terri L Young , Kathryn P Burdon , Pirro G Hysi , Louis R Pasquale , Tien Yin Wong , Caroline C W Klaver , Alex W Hewitt , Jost B Jonas , Paul Mitchell , Andrew J Lotery , Paul J Foster , Veronique Vitart , Norbert Pfeiffer , Jamie E Craig , David A Mackey , Christopher J Hammond , Janey L Wiggs , Ching-Yu Cheng , Cornelia M van Duijn , Stuart MacGregor	2017-01-15	-
27189481	Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. BMC Genomics Jeremy Pasquier , CÃ©dric Cabau , Thaovi Nguyen , Elodie Jouanno , Dany Severac , Ingo Braasch , Laurent Journot , Pierre Pontarotti , Christophe Klopp , John H Postlethwait , Yann Guiguen , Julien Bobe	2016-05-18	-
26472045	Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm. Dev Biol Elisabeth Ott , BjÃ¶rn Wendik , Monika Srivastava , Frederic Pacho , Sonja TÃ¶chterle , Willi Salvenmoser , Dirk Meyer	2016-03-01	-
26469318	RFX transcription factors are essential for hearing in mice. Nat Commun Ran Elkon , Beatrice Milon , Laura Morrison , Manan Shah , Sarath Vijayakumar , Manoj Racherla , Carmen C Leitch , Lorna Silipino , Shadan Hadi , MichÃ¨le Weiss-Gayet , EmmanuÃ¨le Barras , Christoph D Schmid , Aouatef Ait-Lounis , Ashley Barnes , Yang Song , David J Eisenman , Efrat Eliyahu , Gregory I Frolenkov , Scott E Strome , BÃ©nÃ©dicte Durand , Norann A Zaghloul , Sherri M Jones , Walter Reith , Ronna Hertzano	2015-10-15	-
26116175	Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling. Dev. Biol. Ariel Rydeen , Norine Voisin , Enrico D'Aniello , Padmapriyadarshini Ravisankar , Claire-Sophie Devignes , Joshua S Waxman	2015-09-01	cryaa, aldh1a2, egr2b, eng2a, cyp26a1, myod1, myl7, vmhc, nkx2.5, cyp26b1, myh6, six6b, cyp26c1, rarab, hsp70l, rdh10a, hoxb5b
26180064	Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish. Proc. Biol. Sci. Yohey Ogawa , Tomoya Shiraki , Daisuke Kojima , Yoshitaka Fukada	2015-08-07	cadpsb, gnat1, gnat2, tbx2b, rho, opn1lw1, opn1sw2, opn1mw1, opn1mw4, opn1sw1, thrb, six7, six3a, six3b, otx5, opn1mw2, opn1mw3, slc6a13, fkbp5, six6a, six1b, arr3a, opn1lw2, nr2e3, six1a, six6b, nrl, slc6a13l, six2b, six4b, six4a, six5, arr3b, crx, six2a
26034287	Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Proc. Natl. Acad. Sci. U.S.A. Carlos GÃ³mez-MarÃn , Juan J Tena , Rafael D Acemel , Macarena LÃ³pez-Mayorga , Silvia Naranjo , Elisa de la Calle-Mustienes , Ignacio Maeso , Leonardo Beccari , Ivy Aneas , Erika Vielmas , Paola Bovolenta , Marcelo A Nobrega , Jaime Carvajal , JosÃ© Luis GÃ³mez-Skarmeta	2015-06-16	Six1, Six2, Six3, Six4, Six6, lrrc9, prkcha, six3a, six3b, ppm1ba, zfp36l2, slc38a6, prdx3, glud1b, hif1ab, six6a, six1b, tm9sf3, mnat1, six1a, six6b, lrpprc, slc3a1, trmt5, six2b, six4b, six4a, prepl, six2a
25420467	Time point-based integrative analyses of deep-transcriptome identify four signal pathways in blastemal regeneration of zebrafish lower jaw. Stem Cells Hui Zhang , Xuelong Wang , Kailun Lyu , Siqi Gao , Guan Wang , Chunxin Fan , Xin A Zhang , Jizhou Yan	2015-03-01	fgfr4, wisp2, sox10, sox19a, wnt4a, foxa2, wnt2, foxg1a, wnt11r, wnt10b, foxn4, hoxb5a, pou3f3b, hoxa2b, pou5f3, pou6f1, hoxb2a, hoxb3a, hoxb8a, hoxc4a, hoxd3a, hoxb1b, hoxa11b, pou3f2b, pou3f1, hoxd10a, hoxd11a, hoxb8b, pax2a, wif1, pax3a, foxa1, sox21a, foxd3, foxa3, pax6a, pax7a, sox11a, six7, bmp2a, six3a, bmpr1ba, bmp15, sox4a, foxi1, fgf10a, sox2, fgf1a, fgf13b, fgfr1op, bambib, hoxc8a, paxip1, bmp2k, six1a, fgfrl1b, six6b, col11a1b, foxp2, sox14, col10a1a, hoxb13a, col11a2, col2a1a, bmp10, pax1a, col5a2a, col11a1a, foxf1, foxo1b, fgf4, foxh1, hoxb7a, hoxc6b, hoxc1a, hoxa9a, hoxa9b, hoxa4a, hoxa1a, hoxb6b, hoxa5a, pou4f1, bmpr1aa, sox9a, sox9b, fgf8b, six4b, six4a, foxn3, fgf21, fgf10b, fgf12a, wnt11, wisp1b, foxc1b, col8a2, foxb1b, six2a
24150847	Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age. Hum. Mol. Genet. Adriana I Iglesias , HenriÃ«t Springelkamp , Herma van der Linde , Lies-Anne Severijnen , Najaf Amin , Ben Oostra , Christel E M Kockx , Mirjam C G N van den Hout , Wilfred F J van Ijcken , Albert Hofman , AndrÃ© G Uitterlinden , Rob M Verdijk , Caroline C W Klaver , Rob Willemsen , Cornelia M van Duijn	2014-03-01	cdkn2d, dacha, dachb, six3a, six3b, six6a, six6b, cdkn2c, SIX6

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