| Type | Description |
|---|---|
| Definition | phosphatidylinositol 4-kinase type 2 alpha |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:25:00 | Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. | 31554935 |
| 2019-12-14 12:09:00 | both integrin alpha3beta1 and PI4KIIalpha co-localized to the trans-Golgi network, where they physically interacted with each other, and PI4KIIalpha specifically associated with integrin alpha3 but not alpha5 | 30659093 |
| 2019-02-23 12:24:00 | These results indicate that GABARAP and PI4K2A interact tightly. Although lipidation of GABARAP is essential for its role in autophagy, here we show that its lipidation is not required for the interaction of GABARAP and PI4K2A. | 29792687 |
| 2017-12-16 11:13:00 | PI-273 is the first substrate-competitive, subtype-specific inhibitor of PI4KIIalpha, the use of which will facilitate evaluations of PI4KIIalpha as a cancer therapeutic target. | 28827373 |
| 2017-09-23 10:52:00 | Mining oncogenomic databases revealed that loss of the PI4K2B allele and underexpression of PI4KIIbeta mRNA are associated with human cancers. This finding supports the cell data and suggests that PI4KIIbeta may be a clinically significant suppressor of invasion. | 27798239 |
| Type | IDs |
|---|---|
| Synonymous | PI4KII, PIK42A |
| Gene |
UniProtKB-ID:
P4K2A_HUMAN
UniprotKB:
Q9BTU6
UniParc:
UPI0000071D95
EMBL:
AJ303098,
AL353952,
AL355315,
BC003167,
BT007330,
CH471066
Ensembl:
ENSG00000155252
KO:
hsa:55361
|
| Nucleutide sequences |
EMBL-CDS:
EAW49906.1,
AAH03167.1,
CAC38065.1,
AAP35994.1,
CAB89254.1,
EAW49907.1
Ensembl_TRS:
ENST00000370631
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000359665
RefSeq:
NP_060895.1
|
| Others |
UniRef100:
UniRef100_Q9BTU6
UniRef90:
UniRef90_Q9BTU6
UniRef50:
UniRef50_Q9BTU6
UniGene:
Hs.25300
CCDS:
CCDS7469.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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