| Type | Description |
|---|---|
| Definition | ring finger protein 121 |
| Date | Results | Publications |
|---|---|---|
| 2019-08-17 10:35:00 | we identified and characterised oncogenic fusion genes and their function in CRC, and implicated NAGLU-IKZF3 and RNF121-FOLR2 as novel molecular targets for personalised medicine development. | 29955133 |
| 2018-09-15 10:39:00 | Study found that RNF121 was less expressed in tumor tissues than adjacent normal tissues of renal cell carcinoma (RCC) patients. Overexpression of RNF121 inhibited the growth of human RCC cells in vivo. Moreover, RNF121 impeded the proliferation, migration and invasion of human RCC cells in vitro. In addition, RNF121 was found to activate NF-kappaB signaling pathway via promoting IkappaBalpha degradation in RCC cells. | 30149063 |
| 2016-11-05 10:05:00 | Over-expression of RNF121 promoted ubiquitination of VEGFR-2, inhibited its maturation . RNF121 knockdown in primary endothelial cells reduced VEGFR-2 ubiquitination and increased its cell surface level. | 26602861 |
| 2015-10-24 10:47:00 | These results unveil an unexpected role of Golgi Apparatus and reveal RNF121 as a new player involved in the signaling leading to NF-kappaB activation. | 25388546 |
| 2015-06-06 12:42:00 | This is the first study to demonstrate that RNF121 is a novel regulator of apoptosis and provides a new potential target for cancer therapy | 24928685 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
RN121_HUMAN,
C9JQY5_HUMAN
UniprotKB:
Q9H920,
C9JQY5
UniParc:
UPI000013F933,
UPI000006FB75,
UPI000198C538
EMBL:
CH471076,
BC063680,
AK094508,
BC009672,
CR457298,
AP002490,
AK023139
Ensembl:
ENSG00000137522
KO:
hsa:55298
|
| Nucleutide sequences |
EMBL-CDS:
BAB14423.1,
EAW74810.1,
AAH09672.2,
BAG52880.1,
AAH63680.1,
CAG33579.1
Ensembl_TRS:
ENST00000361756,
ENST00000393713
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000354571,
ENSP00000377316
RefSeq:
XP_006718692.1,
XP_006718695.1,
NP_001287855.1,
XP_006718693.1,
NP_060790.2,
XP_024304372.1,
XP_011543452.1
|
| Others |
UniRef100:
UniRef100_Q9H920,
UniRef100_C9JQY5
UniRef90:
UniRef90_Q9H920,
UniRef90_C9JQY5
UniRef50:
UniRef50_C9JQY5,
UniRef50_Q9H920
UniGene:
Hs.368554
CCDS:
CCDS8203.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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