| Type | Description |
|---|---|
| Definition | nei like DNA glycosylase 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:17:00 | An autoinhibitory role for the GRF zinc finger domain of DNA glycosylase NEIL3. | 32878989 |
| 2020-05-23 12:43:00 | TRAIP is important for the recruitment of NEIL3 but not FANCD2, and knockdown of TRAIP promotes FA/BRCA pathway activation. Interestingly, TRAIP is non-epistatic with both NEIL3 and FA pathways in psoralen-ICL repair, suggesting that TRAIP may function upstream of the two pathways. | 31980815 |
| 2020-01-11 10:58:00 | Results indicate that whilst specificity for 5-hydroxyuracil and thymine glycol was observed, NEIL3 preferentially excises oxidized bases from single stranded DNA and within open fork structures. | 31018584 |
| 2019-08-03 12:46:00 | NEIL3 cleaves psoralen-induced DNA-DNA cross-links in three-stranded and four-stranded DNA substrates to generate unhooked DNA fragments containing either an abasic site or a psoralen-thymine monoadduct. Nei and NEIL1 also cleave a psoralen-induced four-stranded DNA substrate to generate 2 unhooked DNA duplexes with a nick; NEIL3 targets both DNA strands in interstrand cross-links without generating single-strand breaks. | 29234069 |
| 2019-07-20 10:14:00 | NEIL1 and NEIL3 may protect cells against cytotoxic and mutagenic effects of NM-Fapy-dG, but NEIL1 may have a unique role in initiation of base excision repair of AFB1-Fapy-dG | 30448017 |
| Type | IDs |
|---|---|
| Synonymous | FGP2, FPG2, NEI3, ZGRF3, hFPG2, hNEI3 |
| Gene |
UniProtKB-ID:
NEIL3_HUMAN
UniprotKB:
Q8TAT5
UniParc:
UPI000013D53D
EMBL:
AK001720,
BC025954,
DQ310721,
AC027627,
AB079071
Ensembl:
ENSG00000109674
KO:
hsa:55247
|
| Nucleutide sequences |
EMBL-CDS:
BAA91860.1,
BAC06479.1,
ABC40719.1,
AAH25954.1
Ensembl_TRS:
ENST00000264596
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000264596
RefSeq:
XP_016863849.1,
NP_060718.3
|
| Others |
UniRef100:
UniRef100_Q8TAT5
UniRef90:
UniRef90_Q8TAT5
UniRef50:
UniRef50_Q8TAT5
UniGene:
Hs.405467
CCDS:
CCDS3828.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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